Cholinoceptor-Activating and Cholinesterase-Inhibiting Drugs Flashcards Preview

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Flashcards in Cholinoceptor-Activating and Cholinesterase-Inhibiting Drugs Deck (13):
1

Which drug is being referred to?
A direct-acting cholinomimetic which activates M1-M3 receptors. It is used for bladder and bowel atony. Side effects include cyclospasm, diarrhea, urinary urgency, vasodilation, reflex tachycardia and sweating.
A. Betanechol
B. Carbachol
C. Pilocarpine
D. Cevimeline
E. Varenicline
F. Edrophonium
G. Neostigmine
H. Pyridostigmine
I. Physostigmine
J. Ambenonium
K. Demecarium
L. Echothiophate

Betanechol

2

Which drug is being referred to?
A direct-acting cholinomimetic which acts on both M and N receptors.
A. Betanechol
B. Carbachol
C. Pilocarpine
D. Cevimeline
E. Varenicline
F. Edrophonium
G. Neostigmine
H. Pyridostigmine
I. Physostigmine
J. Ambenonium
K. Demecarium
L. Echothiophate

Carbachol

3

Which drug is being referred to?
A direct-acting cholinomimetic which activates M3 receptors in ciliary muscle (increasing aqueous humor outflow) and salivary glands (increasing salivation).It is used for glaucoma, Sjogren syndrome, and Sicca syndrome. Side effects include miosis, and blurring of vision due to cyclospasm.
A. Betanechol
B. Carbachol
C. Pilocarpine
D. Varenicline
E. Edrophonium
F. Neostigmine
G. Pyridostigmine
H. Physostigmine
I. Ambenonium
J. Demecarium
K. Echothiophate

Pilocarpine

NOTE: Cevilamine also acts on M3 receptors.

4

Which drug is being referred to?
A direct-acting cholinomimetic which activates ACh receptors (Nn and Nm) and is used for smoking cessation. Side effects include generalized ganglionic stimulation (hypertension, tachycardia, nausea, vomiting). Overdose leads to convulsions, paralysis, and coma.
A. Betanechol
B. Carbachol
C. Pilocarpine
D. Varenicline
E. Edrophonium
F. Neostigmine
G. Pyridostigmine
H. Physostigmine
I. Ambenonium
J. Demecarium
K. Echothiophate

Varenicline

5

Which drug is being referred to?
An indirect-acting cholinomimetic which inhibits cholinesterase, thereby amplifying endogenously released acetylcholine. It is used for the diagnosis of myasthenia gravis (tensilon test) and for the differentiation of myasthenia crisis from cholinergic crisis. Side effects include miosis, salivation, nausea, vomiting, diarrhea, and bradycardia.
A. Betanechol
B. Carbachol
C. Pilocarpine
D. Varenicline
E. Edrophonium
F. Neostigmine
G. Pyridostigmine
H. Physostigmine
I. Ambenonium
J. Demecarium
K. Echothiophate

Edrophonium

NOTE: Edrophonium improves muscle in myasthenic crisis. It weakens muscle strength in cholinergic crisis.

6

Which drug is being referred to?
An indirect-acting cholinomimetic which inhibits cholinesterase, thereby amplifying endogenously released acetylcholine. It is used for the treatment of myasthenia gravis and for the reversal of nondepolarizing neuromuscular blockade. Side effects include miosis, salivation, nausea, vomiting, diarrhea, and bradycardia.
A. Betanechol
B. Carbachol
C. Pilocarpine
D. Varenicline
E. Edrophonium
F. Neostigmine
G. Pyridostigmine
H. Physostigmine
I. Ambenonium
J. Demecarium
K. Echothiophate

Neostigmine

NOTE:
SimD -- pyridostigmine, physostigmine, ambenonium

7

Muscarinic effects of neostigmine are blocked by _______________.

atropine

8

Which drug is being referred to?
A carbamate which is used for glaucoma.
A. Betanechol
B. Carbachol
C. Pilocarpine
D. Varenicline
E. Edrophonium
F. Neostigmine
G. Pyridostigmine
H. Physostigmine
I. Ambenonium
J. Demecarium
K. Echothiophate

Demecarium

9

Which drug is being referred to?
An organophosphate which is used for glaucoma.
A. Betanechol
B. Carbachol
C. Pilocarpine
D. Varenicline
E. Edrophonium
F. Neostigmine
G. Pyridostigmine
H. Physostigmine
I. Ambenonium
J. Demecarium
K. Echothiophate

Echothiophate

10

Which drug is being referred to?
Inhibits cholinesterase. Used in Alzheimer's disease. can be given as patch.
A. Betanechol
B. Carbachol
C. Pilocarpine
D. Varenicline
E. Edrophonium
F. Neostigmine
G. Pyridostigmine
H. Physostigmine
I. Ambenonium
J. Demecarium
K. Echothiophate
L. Rivastigmine

Rivastigmine

11

What are the signs and symptoms of organophosphate poisoning?

DUMBBELSS:
Diarrhea
Urination
Miosis
Bronchospasm
Bradycardia
Excitation (skeletal muscle and CNS)
Lacrimation
Sweating
Salivation

12

The first choice antidote for organophosphate poisoning. It competitively blocks all muscarinic receptors.

Atropine

13

A cholinesterase regenerator which is used as an antidote for organophosphate poisoning and nerve gas poisoning.
Side effect: muscle weakness.
Must be administered before 6-8 hours of organophosphate bond with cholinesterase.

Pralidoxime

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