chpt 16- dermatology ppt Flashcards Preview

oral path > chpt 16- dermatology ppt > Flashcards

Flashcards in chpt 16- dermatology ppt Deck (48):
1

inherited defects of ectoderm ally derived anatomic structures

ectodermal dysplasia

2

affects the skin, hair, nails, teeth, sweat glands

ectodermal dysplasia

3

characterized by fine, sparse hair, hypodontia, heat intolerance, periocular hyper pigmentation, xerostomia

ectodermal dysplasia

4

tx for ectodermal dysplasia

-genetic counseling
-prosthetic replacement of teeth

5

Why would an ectodermal dysplasia patient have xerostomia

decreased salivary gland development

6

Tooth problems with ectodermal dysplasia

hypodontia
Cone shaped teeth

7

Benign, autosomal dominant inherited skin disorder manifesting as thick white buccal mucosa bilaterally, may be corrugated or velvety

White sponge nevus (Canon's Disease)

8

Tx for white sponge nevus

none

9

Autosomal dominant condition seen in descendants of North Carolina Indians, with thick white plaques on the buccal mucosa(like white sponge nevus) and the conjunctiva

Hereditary Benign Intraepithelial Dyskeratosis

10

Histology Dr Siversky said to know for Hereditary Benign Intraepithelial Dyskeratosis

Epithelial clefting

11

What 3 diseases show intra-epithelial clefting

1) HBID
2) Darier's Disease
3) Pemphigus Vulgaris

12

Autosomal dominant skin problem with erythematous puritic papules on the trunk and scalp with FOUL ODOR, dystrophic nails (ridged and split)

Keratosis follicularis (Darier’s disease)

13

What is the oral manifestations of Keratosis Follicularis/ Darier’s Disease

multiple white papules

14

How treat Keratosis Follicularis/ Darier’s Disease

Keratolytic agents or emollients

15

Histopathologically identical to Darier’s Disease , but manifests orally as a single white papule

Warty dyskeratosis

16

Where does the single white papule of Warty dsykeratoma appear

hard palate or alveolar ridge

17

Tx for warty dyskeratosis

Excision

18

Autosomal dominant with freckle like lesions in and around oral cavity, on the hands, and having intestinal polyps with a predisposition to go to adenocarcinoma

Peutz Jeghers

19

2 disorders that have intestinal polyposis

1) Peutz Jegers Syndrome
2) Gardner Syndrome

20

What is the difference, as far as the intestinal polyps, between Peutz-Jeghers and Gardners Syndrome

Peutz-Jeghers has benign intestinal polyps while Garderns are going to go malignant

21

Treatment for Peutz-Jeghers

Monitor for intussusceptions or malignant transformation

22

characterized by brown/black freckle like lesions in and around the oral cavity --> perioral and intramural and circumoral pigmentation

Peutz Jegher

23

what percent of Peutz Jegher vs Gardner intestinal polyposis become malignant

PG: 2-3%
Gardner: 100%

24

Autosomal dominant conditions of multiple vascular hamartomas due to decreased blood vessel wall intregrity.

Hereditary Hemorrhagic telangiectasia

25

Another name for HHT

Osler-Weber-Rendu Syndrome

26

Associated with frequent epistaxis, telangiectasias that are intraoral, hands, feet, GI tract, GU tract and eye, includes iron deficiency anemia if severe

Hereditary Hemorrhagic telangiectasia

27

Genetic abnormalities that lead to abnormal collagen manifesting as hypermobile joints, elasticity of skin

Ehler's Danlos

28

Oral manifestations of Ehlers-Danlos

-subluxation of TMJ
-Don’t respond well to surgery due to defective collagen Bruise and bleed easily

29

Chronic inflammatory disease causing white striations, papules or plaques on buccal mucosa, tongue and gingival, thought to be autoimmune related by CD8 T cells causing oral epithelial cells apoptosis

Lichen Planus

30

Demographics for Lichen planus

45-60 y.o (rare in children) Women 2x more than men

31

Is Lichen planus only caused by autoimmune response

No, there can be drugs whose side effects cause a Lichenoid drug reaction, however, that goes away when drugs are stopped. True Lichen planus is chronic

32

Oral manifestation of Lichen Planus

Striae of Wickham

33

skin manifestations of Lichen planus

purple puritic polygonal papules

34

When biopsying Lichen planus, do you biopsy the red or the white area

White area, red will just show ulceration (basement membrane with no epithelial covering)

35

Histology for Lichen Planus

saw tooth rete pegs and loose basal cell layer

36

Which phase of Lichen planus is treated: Reticular or erosive, and with what

Erosive. Corticosteroids because it is autoimmune mediated

37

What can superimpose on top of Lichen planus especially during corticosteroid treatment of the Erosive form

candidiasis

38

Dislodgement of skin by lateral pressure, can be a symptom in multiple diseases

Nikolsky sign

39

2 disease we have been taught that have a positive Nikolsky sign

Pemphigus
Pemphigoid

40

Histologically, which has a change in the basement membrane: Pemphigoid or pemphigous

Pemphigoid (goid goes down to the basement)

41

Histologically, which has intraepithelial separation: Pemphigoid or pemphigous

Pemphigus

42

Which has larger lesions Pemphigoid or pemphigous and why

pemphigoid, because they are thicker (all the way to the basement)

43

Pemphigoid type that affects women over the age of 60 manifesting orally as vesicles or bullae

benign mucous membrane pemphigoid

44

What are the clinical sizes of the benign mucous membrane pemphigoid vesicles and bullae

vesicles are less than 5mm
Bullae are greater than 5 mm

45

What is the histology for benign mucous membrane pemphigoid (Siversky says to be able to ID this for the fina

subepithelial clefting Immunofluorescence at basement membrane

46

Most commonly used antibiotics for treating benign mucous membrane pemphigoid

Tetracycline Niacinamide Nicotinamide

47

If going to treat someone with benign mucous membrane pemphigoid with Dapsone, what must you check first

that they are not Glucose-6-Phosphate dehydrogenase deficient. Can cause aplastic anemia

48

Most common of the autoimmune blistering conditions

bullous pemphigoid