Christie Flashcards Preview

week 53 > Christie > Flashcards

Flashcards in Christie Deck (40)
Loading flashcards...
1

35 y.o. lady

Leiomyomas

2

What neoplasm is associated with types 16 and 18 HPV?

  • All of the above
    • Cervical Squamous Cell carcinoma
    • Type 1 vulvar squamous cell carcinoma
    • Vaginal intraepithelial neoplasia
    • Cervical Intraepithelial neoplasia

3

Why is the cervical transformation zone important?

  • Site of origin of cervical dysplasia and carcinoma

4

T or F: Vaginal Squamous cell carcinoma most often represents spread from squamous cell carcinoma in the cervix or vulva

True

5

False about type II vulvar squamous cell carcinoma

Associated with HPV

6

Risk factors of endometrial carcinoma

  • Obesity
  • Diabetes
  • Hypertension

7

Most common type of endometrial carcinoma

Endometrial adenocarcinoma

8

Characteristics of endometriod endometrial carcinoma?

  • Inactivation of DNA mismatch repair genes and the PTEN gene
  • associated with estrogen excess and endometrial hyperplasia

9

Not a characteristic of serous endometrial carcinoma?

  • Found in perimenopausal or postmenopausal women

10

Risk factors for cervical intraepithelial neoplasia and carcinoma

  • Early age at first intercourse
  • multiple sex partners
  • persistent infection by high-risk strains of papillomavirus

11

The cells on your right in the illustration are

Koilocytes

12

Uterine Leiomyosarcoma

  • Daignostic histologic features are:
    • cytologic atypia
    • tumor necrosis
    • mitotic activity

13

False about ovarian tumors

  • most are malignant

14

What is the breast structure enclosed in the square in this picture?

  • The terminal duct lobular unit (=TDLU)

15

What is the importance of the structure enclosed in the square?

  • milk production
  • origin of most breast carcinomas

16

What is the importance of the lesion depicted in this picture?

  • most common benign tumor of the female breast

17

This lesion occured several years after a 60 year-old lady had a mastectomy and developed chronic lymphedema. it is most likely a 

Angiosarcoma

18

What is the importance of the lesion depicted in this picture?

  • most common malignant stromal tumor of the breast

19

A 60-year-old lady developed a eczematous, scaly, red rash around her nipple. The biopsy is shown in the following picture. The lesion is most likely

Paget's Disease of the nipple

20

What is the importance of the breast lesion

  • There is DCIS in the ductal system of the breast
  • There can be invasive carcinoma elsewhere in the breast

21

45 y.o. lady

Fibrocystic Disease

22

What are the two most typical presentations of breast carcinoma?

  • Lump in the breast
  • abnormal mammogram

23

ER-negative, HER2 negative carcinomas have which molecular changes?

  • Germline BRCA1 mutations, TP53 mutation, and BRCA1 inactivation

24

What are the main risk factors for developement of breast carcinoma?

  • Estrogenic stimulation
  • older age

25

What is the main biologic subgroup of breast carcinoma?

  • estrogen receptor (ER)-positive, HER2-negative

26

What biologic subgroups of breast carcinoma progress the fastest?

 

  • ER-negative, HER2-negative

27

28

ER-negative, HER2 negative carcinomas have which molecular changes?

  • germline BRCA1 muations
  • TP53 mutation
  • BRCA1 inactivation

29

Inhibin

  • found in both men and women

30

What is not produced by Sertoli cells?

  • Testosterone