Christy Sibigtroth

Question 1

1. The following are all characteristics of the G93A SOD1 transgenic mouse EXCEPT:

Answer 1

d. disease onset is approximately 5 months of age

Question 2

Mutations in superoxide dismutase 1 are associated with 20% of ALS cases.

Answer 2

False

Question 3

Despite increasing astrocyte expression throughout disease progression, expression of the astrocytic glutamate transporter EAAT2 was not significantly increased in the cervical spinal cord of human mutant SOD1 mice.

Answer 3

True

Question 4

4. The cervical spinal cord in mice over-expressing human mutant SOD1 is hypothesized to have neuroprotective properties. What is a proposed mechanism for this neuroprotection?

Answer 4

The cervical spinal cord of mutant SOD1 G93A mice have constitutively increased IL-4 expression.

Question 5

5. All of the following cytokines are thought to be neuroprotective EXCEPT:

Answer 5

NOX-2