Chronic Inflammation/Healing and Repair Processes Flashcards Preview

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Flashcards in Chronic Inflammation/Healing and Repair Processes Deck (14):
1

Chronic Inflammation

Inflammation of prolonged duration or slow progress marked histologically by an infiltration of mononuclear cells (lymphocytes, macrophages, plasma cells) often with proliferation of fibroblasts and fibrosis

2

Chronic Pyelonephritis

Chronic inflammation of the kidney involving the tubules and interstitium which results in scarring

3

Crohn's Disease

A recurrent granulomatous and chronic inflammatory disorder that usually affects the terminal ileum or colon but may occur at any level of the GI tract; results in extensive scarring and fistulae

4

Diverticulitis

Trapping of fecal material within the diverticular pouch leads to bacterial overgrowth which provokes an inflammator response

5

Diverticulosis

A colonic disease associated with increasing age in whcih small pockets of mucosa protrude through the muscular wall

6

Giant Cells

Fused macrophages with very large cytoplasm and multiple nuclei; Two types (Langhans horshoe arranged nuclei) (Foreign body clustered or random nuclei)

7

Granulation Tissue

so called because grossly, under the scab, it has a granular appearance; characterized by ingrowth of new blood vessels and scar tissue

8

Granuloma

A specific form of chronic inflammatory response to antigens that cannot be eliminated during the acute inflammatory response; characterized histologically by collections of epitheloid macrophages, rim of lymphocytes, giant cells, and caseus necrosis

9

Healing by primary intention

healing, following surgical closure, or a wound where the edges are naturally brought together so that only a minimum amount of scar formation occurs

10

Healing by secondary intention

healing, without the intervention of a surgeon, of a large open wound, leading to extensive scarring

11

Keloid

and exaggerated form of scar that protrudes upward from the skin that is characterized by the presence of dense connective tissue (more prevalent in african americans)

12

Miliary

Multiple minute deposites that resmeble "millet seeds"

13

Scar

A collection of collagen that is the end result of repair of an injury

14

Ulcer

A local tissue defect, or excavation involving the epithelial surface of an organ or tissue (think healing by secondary intention)