CLASP - Immunology Flashcards Preview

AB 3rd Year General > CLASP - Immunology > Flashcards

Flashcards in CLASP - Immunology Deck (40):
1

what is type 1 HS?

IgE mediated

2

first step in type 1 HS?

allergen specific B cells encounter allergen and produce IgE specific to the allergen

3

what does IL-4 do?

IgE class switching on B cells

4

what do IL 13+5 do?

recruitment and activation of eosinophils and mast cells

5

what happens to mast cells?

degranulate
due to IgE binding to Fc receptors and crosslinking

6

what is Fc region?

constant region on an antibody

7

what is type 2 HS?

IgM and IgG mediated

8

what is type 3 HS?

immune complex mediated

9

what causes damage in type 3?

C3a + C5a

10

what is type 4 HS? what causes damage?

T cell mediated, with CD8+ causing damage

11

e.g of each type of HS?

1 - anaphylaxis
2 - transfusion reaction
3 - SLE
4 - contact dermatitis

12

Ix for allergy? +ve?

skin prick
local wheal and flare

13

when is serum tryptase done?

after anaphylaxis

14

first Ig produced in immune response?

IgM

15

large vessel vasculitis?

GCA
takayasu

16

medium vessel vasculitis?

PN
kawasaki

17

ANCA small vessel vasculitis? what is tests?

MPA anti MPO (p-anca)
EGPA anti PR3 (c-anca)
GPA anti MPO (p-anca)

18

immune complex small vessel vasculitis?

henoch schonlein

19

features of Takayasus?

difference in BP
stroke mimic
bruits
claudication of extremity

20

Ix for Takayasus?

CT angiogram
PET

21

Ix for goodpastures?

anti GBM antibodies
renal biopsy

22

what can cause primary immunodeficiency?

defects in antibody production

23

features of primary immunodeficiency?

resp infections
GI infections
autoimmune disease

24

features of T cell deficiency?

deep bacterial infections
fungal infections
TB
viral infections
HARD TO TREAT

25

diagnosis of chronic granulomatous disease? what type of disease?

T cell deficiency
X linked or aut recessive
severe infections early on

26

what is SCID?

lack of T cells and impaired B cell function

27

features of SCID?

failure to thrive within first year of life
usually fatal
resp infections/PCP/GI infections

28

Ix for complement deficiency diseases?

CH50 and AP50 test

29

what is LAD?

decreased expression of CD18 on neutrophils and mutation in Beta 2 integrin gene

30

features of LAD?

leucocytosis
recurrent bacterial infections

31

features of X linked agammaglobulinaemia?

poor Ig response to vaccines
serum Ig levels low
recurrent RT/ENT infections

32

features of CVID?

recurrent RT/ENT infections

33

what can cause secondary immunodeficiency?

HIV
chemo
lymphoma

34

what mutation is X linked agammaglobulinaemia?

Btk

35

what is a feature of complement deficiency disease?

repeated meningitis

36

most frequently diagnosed immunodeficiency is?

selective IgA deficiency

37

what do glucocorticoids do?

increase protein breakdown
leading to gluconeogenesis

38

first respone Ig?

IgM

39

Ig from breast milk?

IgA

40

what Ig comes from placenta?

IgG