Classic Labs/Findings: Lab/Diagnostic Finding//Diagnosis/Disease Flashcards Preview

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Flashcards in Classic Labs/Findings: Lab/Diagnostic Finding//Diagnosis/Disease Deck (25):
1

Anticentromere antibodies

Scleroderma (CREST)

2

Antihistone antibodies

Drug-induced SLE

(hydralazine, INH, phenytoin, procainamide)

3

Antinuclear antibodies (ANAs: anti-Smith and anti-dsDNA)

SLE (type III hypersensitivity)

4

Antiplatelet antibodies

Idiopathic thrombocytopenic purpura (ITP)

5

Basophilic nuclear remnants in RBCs

Howell-Jolly bodies (due to splenectomy or nonfunctional spleen)

6

Bloody tap on LP

Subarachnoid hemorrhage

7

Stacks of RBCs

Rouleaux formation (high ESR, multiple myeloma)

8

Psammoma bodies

Meningiomas
papillary thyroid carcinoma
mesothelioma
papillary serous carcinoma of the endometrium and ovary

9

Pseudopalisading tumor cells on brain biopsy

Glioblastoma multiforme

10

Heterophile antibodies

Infectious mononucleosis (EBV)

11

High level of D-dimers

DVT
PE
DIC

12

Hypochromic, microcytic anemia

Iron deficiency anemia
lead poisoning
thalassemia (fetal hemoglobin sometimes present)

13

Lytic ("hole punched") bone lesions on x-ray

Multiple myeloma

14

Hypersegmented neutrophils

Megaloblastic anemia (B12 deficiency: neurologic symptoms; folate deficiency: no neurologic symptoms)

15

Needle-shaped, negatively birefringent crystals

Gout (monosodium urate crystals)

16

Depigmentation of neurons in the substantia nigra

Parkinson disease (basal ganglia disorder: rigidity, resting tremor, bradykinesia)

17

Extracellular (A-beta) amyloid deposition in gray matter of brain

Senile plaques (Alzheimer disease)

18

Giant B cells with bilobed nuclei with prominent inclusions ("owl's eyes")

Reed-Sternberg cells (Hodgkin lymphoma)

19

"Hair on end" (crew-cut) appearance on x-ray

Beta-thalassemia, sickle cell anemia (marrow expansion)

20

Basophilic stippling of RBCs

Lead poisoning or sideroblastic anemia

21

Anti-topoisomerase antibodies

Diffuse systemic scleroderma

22

Anti-glomerular basement membrane antibodies

Goodpasture syndrome (glomerulonephritis and hemoptysis)

23

Degeneration of dorsal column nerves

Tabes dorsalis (Tertiary syphilis)

(differentiated from subacute combined degeneration [B12 deficiency], where dorsal columns and lateral corticospinal tracts are affected)

24

Silver-staining spherical aggregation of tau proteins in neurons

Pick bodies (Pick disease: progressive dementia, changes in personality)

25

Sheets of medium-sized lymphoid cells with scattered pale, tingible body-laden macrophages ("starry sky" histology)

Burkitt lymphoma (t:[8;14] c-myc activation, associated with EBV; "black sky" made up of malignant cells)