Classic Presentations 2 Flashcards Preview

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Flashcards in Classic Presentations 2 Deck (37):
2

Pupil accommodates but doesn't react

Argyll Robertson pupil (neurosyphilis)

((Prostitutes pupil))

3

Rapidly progressive leg weakness that ascends (following GI/upper respiratory infection)

Guillain-Barre syndrome (autoimmune acute inflammatory demyelinating polyneuropathy)

4

Rash on palms and soles

Coxsackie A, Secondary syphilis, Rocky Mountain spotted fever

5

Recurrent colds, unusual eczema, high serum IgE

Hyper-IgE syndrome (Job's syndrome: neutrophil chemotaxis abnormality)

6

Red "currant jelly" sputum in alcoholic or diabetic patients

Klebsiella pneumoniae

7

Red, itchy, swollen rash of nipple/areola

Paget's disease of the breast (represents underlying neoplasm)

8

Red urine in the morning, fragile RBC's

Paroxysmal nocturnal hemoglobinuria

9

Renal cell carcinoma (bilateral), hamangioblastomas, angiomatosis, pheochromocytoma

von Hippel-Lindau disease (dominant tumor suppressor gene mutation)

10

Resting tremor, rigidity, akinesia, postural instability

Parkinson's disease (nigrostriatal dopamine depletion)

11

Retinal hemorrhages with pale centers

Roth's spots (bacterial endocarditis)

12

Sever jaundice in neonate

Crigler-Naijar syndrome (congenital unconjugated hyperbilirubinemeia)

13

Sever RLQ pain with rebound tenderness

McBurney's sign (appendicitis)

14

Short stature, increased incidence of tumors/leukemia, aplastic anemia

Fanconi's anemia (genetic loss of DNA crosslink repair; often progresses to AML)

15

Single palm crease

Simian crease (Down syndrome)

16

Situs inversus, chronic sinusitis, bronchiectasis, infertility

Kartanger's synderome (dynein arm defect affecting cilia)

17

Skin hyperpigmentation

Addison's disease (primpary adrenocortical insufficiency causes increased ACTH and alpha-MSH production)

18

Slow, progressive muscle weakness in boys

Becker's muscular dystrophy (X-linked missense mutation in dystrophin; less severe than Duchenne's)

19

Small, irregular red spots on buccal/lingual mucosa with blue-white centers

Koplik spots (measles; rubeola virus)

20

Smooth, flat, moist white lesions on genitals

Condylomata lata (secondary syphilis)

21

Splinter hemorrhages in fingernails

Bacterial endocarditis

22

"Strawberry tongue"

Scarlet fever, Kawasaki disease, toxic shock syndrome

23

Streak ovaries, congenital heart disease, horseshoe kidney, cystic hygroma at birth

Turner Syndrome (45XO, short stature, webed neck, lymphedema)

24

Sudden swollen/painful big toe joint, tophi

Gout/podagra (hyperuricemia)

25

Swollen gums, mucous bleeding, poor wound healing, spots on skin

Scurvy (Vitamin C deficiency: can't hydroxylate proline/lysine for collagen synthesis)

26

Swollen , hard, painful finger joints

Osteoarthritis (osteophytes on PIP [Bouchard's nodes], DIP [Heberden's nodes])

27

Systolic ejection murmur (crescendo-decrescendo)

Aortic valve stenosis

28

Thyroid and parathyroid tumors, pheochromocytoma

MEN 2A (autosomal dominant ret mutation)

29

Thyroid tumors, pheochromocytoma, ganglioneuromatosis

MEN 2B (autosomal dominant ret mutation)

30

Toe extension/fanning upon plantar scrape

Babinski Sign (UMN lesion)

31

Unilateral facial drooping involving the forehead

Bell's palsy (LMN CN7 palsy)

32

Urethritis, conjunctivitis, arthritis in a male

Reactive arthritis associated with HLA-B27

33

Vascular birthmark (port-wine stain)

Hemangioma (benign, but associated with Sturge-Weber syndrome)

34

Vomiting blood following esophagogastric lacerations

Mallory-Weiss syndrome (alcoholic and bulimic patients)

35

"Waxy" casts with very low urine flow

Chronic end-stage renal disease

36

WBC casts in urine

Acute pyelonephritis

37

Weight loss, diarrhea, arthritis, fever, adenopathy

Whipple's disease (Tropheryma whippelii)

38

"Worst headache of my life"

Subarachonid hemorrhage