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Flashcards in Clotting and platelets Deck (17):
1

When do you use IIb/IIIa inhibitors?

Unstable angina
Several days after stent placement

NON-STEMI treated medically

2

Side effect of dipyridamole?

Headache. Need to know

3

Thrombocytopenia need to rule out what?

FOLATE AND B12 and ALCOHOL

4

HIT IS 4 star topic. Talk about mechanism?

Lab?

Thrombosis with thrombocytopenia

Platelet count cut in half

Heparin forms complexes with platelet factor 4

Antibodies against the complex cause platelet activation and aggregation

Platelets removed from circulation

SO YOU ARE HYPERCOAGULABLE

5

Tx of HIT?

Stop heparin (duh)

Give lepirudin or argatroban (direct thrombin inhibitor) (B/c thrombosis)

transition to Warfarin

6

ITP is 4 star topic Immune thrombocytopenia. What do you see with labs? Tx?

Antiplatelet antibodies cause it

less than 50,000

Tx? Kids self limited

Adults: steroids, IVIG, plasmapheresis

7

TTP-HUS is 4 star. Thromboic Thombocytopenic

Mechanism?

OH ok

Mechasnism is metalloprotease is low, so platelets aggregate

Associated with EHEC.

8

What do you see with TTP?

Hemolysis, uremia, thrombocytopenia, neurologic sequelae, FEVER

Pentad in TTP (HUS is the triad so no neuro symptoms or fever) MUST KNOW

9

Tx HUS-TTP?

Steroids, plasmapheresis, FFP

10

What is antiphospholipid syndrome?

When do you get?

Pregnancy, lupus, other stuff

Thrombosis happens b/c damage to endothelium

11

HELLP syndrome?

Hemolysis, Elevate Liver, Low Platelets

HTN (b/c associated with preeclempsia)

Tx? Deliver baby

12

Labs with Von willebrands?

High PTT, High BT, normal platelet count (platelets just can't bind)

Low ristocetin cofactor activity

13

H and P in von willebrands?

Easy bruising, MENNORHAGIA, muscusal bleeding

14

Clotting factors not from liver?

vWF not from liver neither is Factor XIII, so still up in liver failure

15

H&P for DIC?

Jaundice, b/c hemolysis form thrombin that cells go through

Cyanosis
Hypotension
Uncontrolled bleeding

16

True or false, you give heparin for DIC?

Actually, kind of true, b/c may be hyeprcoagulable state that started this

17

Hypercysteinemia causes what blood clotting wise?

hypercoagulable MTHFR