CM LEC - Synovial Fluid Flashcards Preview

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Flashcards in CM LEC - Synovial Fluid Deck (59):
1

Often referred as “joint fluid”

-

synovial fluid

2

- A viscous fluid found in the cavities of the movable
joints (diarthroses) or synovial joints

synovial fluid

3

Contained in a cavity that separates the articular cartilage which lines the bones in the synovial joints

synovial fluid

4

lines the bones in the synovial joints

articular cartilage

5

synovial fluid is found in

cavities of the movable
joints (diarthroses) or synovial joints

6

other name of synovial fluid

joint fluid

7

bones in synovial joints are separated by a ___
this __ also contains the synovial fluid

cavity

8

2 parts of synovial joint which reduce the friction between bones during joint movement

smooth articular cartilage
synovial fluid

9

- Provides nutrients to the articular cartilage

synovial fluid

10

lessens the shock of compression occurring during activities such as walking & jogging

synovial fluid

11

Formed as an ultrafiltrate of plasma across the synovial membrane

synovial fluid

12

specificity of filtration of synovial fluid

nonselective filtration except for high molecular weight proteins

13

most of the chemical constituents of synovial fluid is similar to ___ values due to the nonselective filtration of synovial fluid

plasma

14

- Viscosity is caused by the secreted mucopolysaccharide containing ___ of the synoviocytes

hyaluronic acid

15

specialized cells of synovial fluid

synoviocytes

16

hyaluronic acid in the mucoploysaccharide causes __

viscosity

17

damage to the articular membranes that
produces pain & stiffness in the joints

Arthritis

18

joint disorders classification
Microbial infection

septic

19

joint disorders classification
Degenerative joint disorder

non inflammatory

20

joint disorders classification
Crystal induced gout & pseudogout

inflammatory

21

joint disorders classification
Immunologic problems, including rheumatoid arthritis & lupus erythematosus

inflammatory

22

joint disorders classification
Traumatic injury

hemorrhagic

23

joint disorders classification
Coagulation deficiencies

hemorrhagic

24

Most frequently performed tests (5)

 WBC count
 Differential
 Gram stain
 Culture
 Polarized microscopy examination for crystals

25

synovial fluid Collected by ___

needle aspiration (arthrocentesis)

26

Amount of fluid present varies with __ (2)

joint size &
degree of fluid build up in the joint

27

sx collection and handling
_____ collected should be recorded

Volume of liquid

28

does normal SF clot or not?

- Normal synovial fluid does not clot

29

Fluid is usually collected in a __ moistened with heparin

syringe

30

Fluid is usually collected in a syringe moistened with __

heparin

31

Sufficient fluid is distributed into 3 tubes

#1- sterile heparinized: microbiology lab
#2 – liquid EDTA tube: hematology lab
#3 – nonanticoagulated tube: other tests

32

tube # 1 lab

microbio

33

tube #2 lab

hema

34

tube #3 lab

*other tests

35

tube #1 contains what type of specimen

sterile heparinized

36

tube #2 contains what type of specimen

liquid EDTA tube

37

tube #3 contains what type of specimen

nonanticoagulated

38

Powdered coagulants should not be used because they may produce ___ that will interfere with crystal analyses

artifacts

39

____ should not be used because they may produce artifacts that will interfere with crystal analyses

Powdered coagulants

40

artifacts interfere with what analysis

crystal

41

All testing should be done as soon as possible to
prevent (2)

cellular lysis & possible changes in crystals

42

Appearance & Viscosity
 Normal - ?



 Milky – presence of crystals

clear & pale yellow

43

 Deeper yellow -

presence of inflammation

44

Greenish

bacterial infection

45

Turbidity (3)

presence of WBCs
synovial cell debris
fibrin

46

 Milky

presence of crystals

47

property of SF essential for proper lubrication

viscosity

48

viscosity caused by __ of hyaluronic acid

polymerization

49

condition which decreases viscosity

arthritis

50

simplest method to measure viscosity is the ______

ability of the fluid to form a string from the tip of a syringe

51

Normal string measures ?? cm

4 to 6cm

52

used to measure the degree of hyaluronate
polymerization aside from the string test

Ropes, or Mucin Clot Tests

53

in the mucin clot test, normal synovial test is added to a solution of __

2-5% acetic acid

54

normal result in the mucin clot test

solid clot
surrounded by clear fluid

55

Synovial fluid lactate
- provide rapid differentiation between _____

inflammatory & septic arthritis

56

> 250 mg/dl lactate levels is seen in what types of arthritis

septic, rheumatoid

57

serologic test is used for diagnosis of ____

joint disorders

58

Rheumatoid arthritis &lupus erythromatosus are diagnosed by demonstrating WHAT

the presence of their particular antibodies in the patient’s serum

59

Demostration of antibodies to the causative agent Borrelia burgdorgeri in the patient’s serum can ___

confirm the cause of the arthritis

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