CNS, Anesthetic, Relaxant, Psychiatric, and Opiod Drugs Flashcards Preview

Pharmacology > CNS, Anesthetic, Relaxant, Psychiatric, and Opiod Drugs > Flashcards

Flashcards in CNS, Anesthetic, Relaxant, Psychiatric, and Opiod Drugs Deck (41):
1

Mnemonics-GABA receptors effects

FREnzodiazepines: FREquency
BarbiDURATes: DURATion

2

What abnormal sleep pattern results from the use of benzodiazepines?

decreased REM sleep

3

Which benzodiazepine has the longest half-life?

CHLORDIAZEPOXIDE has the longest half-life (36-200 hours) and the longest spelling (many letters)

4

Which drugs are considered date-rape drugs?

Alcohol (most common)
Flunitrazepam (rohypnol)
Gamma-hydroxybutyrate

5

Mnemonics-Thiopental

TAYOpental=TAYO agad (shortest acting)

6

What enzyme is deficient in acute intermittent porphyria?

HMB synthase

7

What is the most catastrophic symptom of sedative-hypnotic withdrawal?

rebound suicide

8

Mnemonics-Zolpidem

zzZZzzZZzzZZzz (sleep)
Zolpidem, Zaleplon = Zleep disorders

9

Mnemonics-Buspirone

Buspirone for Busy People (Always Anxious)
BuSPirone like your BenzodiaSePine

10

Mnemonics-Wernicke-Korsakoff Syndrome

Weird ACO = Wernicke-Korsakoff Syndrome
-Ataxia, confusion, Ophthalmoplegia

11

What changes in the brain are seen in Wernicke-Korsakoff syndrome?

Hemorrhagic necrosis of the mamillary bodies

12

Mnemonics-Delirium Tremens

H-A-D 48
Hallucinations
Autonomic instability
Delirium
48-72 hours post-discontinuation

13

What drugs can cause disulfiram reaction?

Clara took the Pre-Medical Test in the PM
Chlorpropamide
Cefo Perazone
Mandole
Tetan
Procarbazine
Metronidazole

14

How will you distinguish whether local anesthetics are esters or amides?

ESTERS have only 1 i in their names.
Tetracaine, Procaine, Benzocaine
AMIDES have 2 i's in their names.
Bupivacaine, Ropivacaine, Lidocaine

15

Which local anesthetics have the shortest and the longest half-lives?

PROCAINE = shortest half-life (1-2 mins)
A PRO finishes the race fastest.
ROPIVACAINE = longest half-life (4.2 hrs)
At the end of the long ROPe.

16

Mnemonics-Delirium Tremens

H-A-D 48
Hallucinations
Autonomic instability
Delirium
48-72 hours post-discontinuation

17

What drugs can cause disulfiram reaction?

Clara took the Pre-Medical Test in the PM
Chlorpropamide
Cefo Perazone
Mandole
Tetan
Procarbazine
Metronidazole

18

How will you distinguish whether local anesthetics are esters or amides?

ESTERS have only 1 i in their names.
Tetracaine, Procaine, Benzocaine
AMIDES have 2 i's in their names.
Bupivacaine, Ropivacaine, Lidocaine

19

Which local anesthetics have the shortest and the longest half-lives?

PROCAINE = shortest half-life (1-2 mins)
A PRO finishes the race fastest.
ROPIVACAINE = longest half-life (4.2 hrs)
At the end of the long ROPe.

20

Why should you NOT inject local anesthetics into an abscess during incision and drainage?

-won't work due to acidic environment
-(below pKa = uncharged form with no anesthetic activity predominates)

21

What is the toxic dose of LIDOCAINE?

toxic dose = 5 mg/kg
for any drug or solution, 1% = 10 mg/mL
For a 70 kg patient:
70 kg x 5 mg/kg = 350 mg toxic dose
If 1% solution is used: 350 mg/10 mg/mL = 35 mL

22

What are the drugs used in lethal injection?

Thiopental (5g)
Pancuronium (100mg)
Potassium Chloride (100mEq)

23

What are the primary signs of Parkinson Disease?

PARKINSON DISEASE
It's a TRAP
Tremor
Rigidity
Akinesia
Postural instability

24

What drugs can cause livedo reticularis?

A man reads FHM and GQ!
Amantadine
Hydroxyurea
Minocycline
Gemcitabine
Quinidine

25

What are the features of neuroleptic malignant syndrome?

NEUROLEPTIC MALIGNANT SYNDROME
Fever
Encephalopathy
Vitals unstable
Elevated CPK
Rigidity

26

Differentiate Malignant Hyperthermia (MH), Serotonin Syndrome (SS), and Neuroleptic Malignant Syndrome (NMS) based on ONSET

MH: Within minutes
SS: Within hours
NMS: 1-3 days

27

What drugs can cause erectile dysfunction?

ERECTILE DYSFUNCTIONS
A SORE PEniS can't Fuck Hard!
SSRIs
Opiates
Risperidone
Ethanol
Propranolol
Estrogens
Spironolactone
Finasteride
Hydrochlorothiazide

28

What drugs can cause priapism?

PRIAPISM
Tigas PeniS Co, AyaW Bumaba!
Trazodone
Papaverine
Sildenafil
Quetiapine
Alprostadil
Warfarin
Bupropion

29

Differentiate Malignant Hyperthermia (MH), Serotonin Syndrome (SS), and Neuroleptic Malignant Syndrome (NMS) based on CLINICAL FEATURES

MH: Fever, Acidosis, Rhabdomyolysis, Trismus, Clonus, Hypertension
SS: Fever, Agitation, Tremor, Clonus, Hyperreflexia, Diaphoresis
NMS: Fever, Encephalophaty, Vitals unstable, Elevated CPK, Rigidity

30

Differentiate Malignant Hyperthermia (MH), Serotonin Syndrome (SS), and Neuroleptic Malignant Syndrome (NMS) based on FIRST-LINE TREATMENT

MH: Dantrolene
SS: Sedation, paralysis, intubation and ventilation, cyproheptadine
NMS: Dantolene + support

31

Differentiate Malignant Hyperthermia (MH), Serotonin Syndrome (SS), and Neuroleptic Malignant Syndrome (NMS) based on PRECIPITATING DRUG

MH: Volatile anesthetics (halothane), succinylcholine
SS: SSRIs, MAOIs, TCAs, meperidine, MDMA, St. John wort
NMS: Antipsychotics

32

Differentiate Malignant Hyperthermia (MH), Serotonin Syndrome (SS), and Neuroleptic Malignant Syndrome (NMS) based on MECHANISM

MH: Massive Calcium release from SR
SS: Excess serotonin
NMS: Dopamine antagonism

33

Differentiate Malignant Hyperthermia (MH), Serotonin Syndrome (SS), and Neuroleptic Malignant Syndrome (NMS) based on CLINICAL FEATURES

MH: Fever, Acidosis, Rhabdomyolysis, Trismus, Clonus, Hypertension
SS: Fever, Agitation, Tremor, Clonus, Hyper

34

Differentiate Malignant Hyperthermia (MH), Serotonin Syndrome (SS), and Neuroleptic Malignant Syndrome (NMS) based on FIRST-LINE TREATMENT

MH: Dantrolene
SS: Sedation, paralysis, intubation and ventilation
NMS: Dantolene + support

35

Differentiate Malignant Hyperthermia (MH), Serotonin Syndrome (SS), and Neuroleptic Malignant Syndrome (NMS) based on OTHER TREATMENT

MH: Cooling
SS: Cooling, cyproheptadine, chlorpromazine
NMS: Cooling, dantrolene, bromocriptine, amantadine, diazepam

36

Which opioids have the shortest and longest half-lives?

REMIFENTANIL = shortest half-life (3-4 mins)
BUPRENORPHINE = longest half-life (4-8 hrs)

37

How do you remember the opioid receptors?

-(MU) receptor = Mabagal hUminga
-(delTa) receptor = Tolerance
-(Kappa) receptor = Konstipation

38

Morphine Effects

Miosis
Orthostatic hypotential
Pulmonary depression
Histamine release
Increased ICP
Nausea
Euphoria

39

What is the triad of opioid overdose?

OPIOID OVERDOSE
P-C-R
Pupillary constriction
Comatose state
Respiratory depression

40

Mnemonics- Cocaine Intoxication

Nakakita ka ng ice-cold coke. Na-excite ka. Nanlaki ang mata mo.
COCAINE = mydriasis

41

Mnemonics-Marijuana Intoxication

BLOODY MARY
MARIJUANA = red conjunctiva