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Flashcards in CNS & Drugs Deck (89)
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1

Generaly describe communication between nerves and synapses

gap junctions
-vesicles store neurotransmiter
-build up of Ca causes release
-bind on on receptors to create stimulus
are either degraded or reuptake occurs

2

How can neurotransmitter imitators create a response

they must mimic the efect of the neurotransmitter

3

How can sensitivity of neurons be influenced

up/down regulation

4

how do agonsits influence neuron sens.

down regulation

5

how do antagonists influence neuron sens.

up regulation

6

Name the excitatory AA of the CNS

-GLU
-ASP

7

name the inhibitory AA

-GLY
-GABA

8

Which Monoamines act in the CNS

-NE
-E
-Dopamine
-Serotonin

9

Which Neuropeptides act in the CNS

-Encephalin
-Endorphins

10

What does Encephalin cause

Resp./circulatory depression

11

What do Endorphins cause

Euphoria

12

Which ion do GABAa rec. bind

Cl-

13

Which types of GABA rec. are there

-A
-B

14

What kind of receptor is the GABAb rec.

G-protein

15

Name the drug categories that depress the CNS in some way

-Sedatives
-Hypnosedatives
-Anti-convulsants
-Analgesics
-General anesthetics
-local anesthetics
-Muscle relaxants

16

How can Tranquillizers/Sedatives be categorized?

-Phenothiazine derivatives
-Butyrophenones

17

Name the Phenothiazine derivatives

-Acepromazine
-Propriopromazine
-Chlorpromazine
-Prometazine

18

Butyrophenones - name them!

-Azaperone
-Droperidol
-Haloperidol
-Fluanisone

19

Name the Tranquillizers/Sedatives

-Acepromazine
-Propriopromazine
-Chlorpromazine
-Prometazine
-Azaperone
-Droperidol
-Haloperidol
-Fluanisone

20

Which effect do Phenothiazineshave on rec.

All antagonistic

21

All Phenothiazines act as antagonists on the rec. t/f

t

22

Name all the rec. the Phenothiazine derivates act on

-Dopaminergic
-alpha adrenorec.
-H1 rec.
-Serotonin
-Muscarinic

23

What do phenothiazines cause on dopaminergic receptors

anti-emetic, anti-psychoitc

24

pharmalogical effects of phenothiazines


-potentiates sedative, hypnotic effect
-central anti emetic effect
-peripheral anti histamine effect

25

Indications of phenothiazines

-calming and sedation
-muscle relaxation
-premed. before analgesia

26

Phenothiazine have a very fast onset t/f

f

27

Describe the pharmacokinetics of the phenothiaznes

-slow onset
-penetrate mucosa
-dose independent
-slowly eliminated
-usually tolerated well

28

Name the SE of Phenothiazines

-hypotension
-bradycardia
-paradox reac. in EQ
-Bulldogs and Boxers are sensitive
-tissue irritation
-epilepsy

29

Which Phenothiazine dreivative has the most frequent SE

Chlorpromazine

30

Which of the Phenothiazine derivatives has good oral bioav.

Acepromazine