Flashcards in CNS Neuropathology Deck (16):
The _____________ often gets "chewed up" in MS.
It is possible to have enlarged ventricles without needing a shunt. Explain.
People can have enlarged ventricles due to loss of periventricular tissue, called hydrocephalus ex vacuo.
MS lesions in the brain often appear at the _______________.
gray-white junction (specifically veins)
MS is more common in _____________ but worse in _____________.
Immunohistochemical staining of ____________ allows for better identification of MS plaques.
myelin basic protein
Looking at a gross brain specimen, how can you tell communicating hydrocephalus?
The outer edges of the brain (near the meninges) will be scarred – preventing the CSF from getting into the sinuses.
Enhancing rings are ___________.
Emboli usually appear at the _________________.
Lewy body dementia spreads from _______________.
the substantia nigra to the limbic system to the cortex
The earliest effects of alcohol seem to be on _____________.
Chronic alcohol abuse leads to ________________.
cortical atrophy and meningeal fibrosis
What part of the cerebellum most often gets damaged in chronic alcohol abuse?
The superior/rostral cerebellar vermis
While MS mostly affects _________ matter, __________ matter is also affected.
Neurocysticercosis might result from eating what?
Toxoplasmosis of the brain is often seen in _____________ patients and presents with _________________.
AIDS or otherwise immunocompromised; mononucleosis-like illness and maculopapular rash