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Flashcards in CNS PATHOLOGY 1 Deck (21)
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1

cells involved in JC virus infection?

oligodendrocyte

2

mech of PML (progressive multifocal leukoencephalopathy)?

- demyelination of CNS due to destruction of oligodendrocytes - associated with JC virus - rapidly progressive

3

2 structures from neural crest?

1. PNS neurons 2. Schwann cells

4

structure from mesoderm?

microglia

5

what pathology is associated with hyperphosphorylated tau protein?

Alzheimer

6

what pathology is associated with silver staining spherical tau protein with an aggressive change in behavior?

Frontotemporal dementia (Pick's dz)

7

what path is associated with alpha synuclein defect with visual hallucination?

Lewy body dementia

8

is ACh increased or decreased in Alzheimer?

decreased

9

what is the cause for communicating hydrocephalus?

decreased CSF absorption by arachnoid granulations

10

what 2 structures make CSF?

1. ependymal cells 2. choroid plexus

11

what condition is associated with arachnoid scarring post-pyogenic meningitis?

communicating hydrocephalus

12

what is normal pressure hydrocephalus?

1. affects elderly 2. CSF pressue elevated only episodically 3. no increased subarachnoid space volume 4. expansion of ventricles --> distorts fibers of corona radiata

13

what is the mech of clinical symptoms in normal pressure hydrocephalus?

expansion of ventricles --> distorts fibers of corona radiata leading to urinary incontinence, ataxia, cognitive dysfunction

14

mechanism of ex vacuo hydrocephalous

the appearance of inc CSF due to decreased brain tissue is seen in Alzheimer diseases etc

15

is ICP increased or decreased in communicating hydrocephalus?

increased

16

Pyogenic meningitis- CSF

Low sugar, increased protein and high pressure

17

Aseptic meningitis

Normal sugar, increased protein and high pressure

18

HIV with dementia and motor defect- biopsy

microglial nodule

19

Repair of the brain- which cell

astrocytes

20

Viral meningitis- prognosis

dementia

21

hemorrhagic meningitis

herpes