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Flashcards in CNS Pharm Deck (25):
1

What is the NT pathophys of Alzheimer's disease?

decreased ACh-M

2

What is the 1a pharm approach in Alzheimer's disease?

increase ACh activity

3

What is the NT pathophys of acute/chronic pain?

abnormal PG, ion channels, 5HT, glutamate

4

What is the NT pathophys of Parkinson's disease?

decreased striatal DA release (leading to increased ACh and increased GABA inhibition)

5

This is due to decreased striatal DA release (leading to increased ACh and increased GABA inhibition).

Parkinson's disease

6

This is caused by abnormal PG, ion channels, 5HT, glutamate.

acute/chronic pain

7

This is caused by decreased ACh-M.

Alzheimer's disease

8

What is the NT pathophys of seizure disorders?

abnormal VSSC-VSCC, decreased GABA and/or increased glutamate

9

This is caused by abnormal VSSC-VSCC, decreased GABA and/or increased glutamate.

seizure disorders

10

What is the 1a pharm approach in Parkinson's disease?

increased DA activity

11

What is the 1a pharm approach in acute/chronic pain?

increase ENK activity, increase NE/5HT, decrease PG formation

12

What is the 1a pharm approach in seizure disorder?

increase GABA activity, block VSSC and VSCC

13

What is the 1a pharm approach in psychoses?

block D2 and 5HT2a receptors

14

What is the 1a pharm approach in depression?

increase synaptic levels of 5HT, NE, and DA

15

What is the 1a pharm approach in mania?

modulate NT activity, block VSSC-VSCC

16

What is the 1a pharm approach in anxiety?

enhance 5HT and GABA

17

What is the 1a pharm approach in ADHD?

increase DA-NE activity

18

What is the 1a pharm approach in insomnia?

increase GABA, decrease ACh and histamine

19

What is the 1a pharm approach in general anethesia?

increase GABA, decrease NMDA-R function

20

What is the NT pathophys of ADHD?

deficient DA-NE

21

What is the NT pathophys of insomnia?

deficient GABA

22

What is the NT pathophys of psychoses?

increased limbic DA with decreased PFC DA

23

What is the NT pathophys of depression?

decreased 5HT-NE or decreased BDNF

24

What is the NT pathophys of mania?

increased NE-DA activity

25

What is the NT pathophys of anxiety?

decreased 5HT-GABA or increased NE overstimulates the amygada