CNS Transmission Flashcards Preview

Hugh's MD1 Neuro > CNS Transmission > Flashcards

Flashcards in CNS Transmission Deck (18):
1

What is the difference between catecholamine production in the CNS and adrenal gland?

NA > adrenaline is possible in the adrenal glands while synthesis stops at NA in neurons

2

Why are there prejunctional receptors for NA?

It is a negative feedback mechanism to regulate its release

2

What is the affect of cocaine on neural activity

Increased responsiveness to neuronal activity

3

What is the mechanism of action of Amphetamines and ephedrine?

It displaces NA from the presynaptic vessels it is contained in causing it to be released non-exocytotically

4

What goes wrong in Parkinson's?

Degeneration of dopaminergic pathways

4

Is GABA excitatory or inhibitory?

Inhibitory

5

What is the neurotransmitter and receptor of the sympathetic NS?

Noradrenaline

Alpha and beta adrenoceptors

5

How can cocaine be used as an anaesthetic?

Block Na channels

7

What is the neurotransmitter and receptor of the parasympathetic NS?

Acetylcholine

Muscarinic receptors

8

What is the mechanism of action of cocaine?

It blocks NA (and other neurotransmitters) reuptake into the presynaptic neurone

10

The receptors for GABA and glutamate are what type?

Ligand gated ion channels

12

What is the mechanism for removal of NA from the synapse?

Reuptake

13

What aspect of cocaine's affect is causes people to be come dependent?

Dopaminergic action (ie blocking dopamine reuptake at the synapse)

14

The physiological response to cocaine is indicative of ... stimulation?

Sympathetic NS

15

Why is L-DOPA used as a treatment for Parkinson's and not dopamine itself?

L-DOPA can get across the BBB (via AA transporters), dopamine can't

16

Is glutamate excitatory or inhibitory?

Excitatory

17

What is the pathology in Huntington's disease?

GABA deficiency

18

What is the neurotransmitter and receptor of the somatic NS?

Acetylcholine 

Nicotinic receptors