CNS Tumors

Question 1

What percentage of CNS tumors are mets?

Answer 1

70%

Question 2

What is the most common CNS tumor in adults?

Answer 2

gliobalstoma multiforme

Question 3

Metastasized lesions are usually found singly/present in groups

Answer 3

groups

Question 4

Pleomorphic

Answer 4

variable shaped cells

Question 5

Adjuvant therapy

Answer 5

following primary treatment

Question 6

Adult vs. child tumor locations

Answer 6

adult: supratentorial 70%
children: posterior fossa 70%

Question 7

WHO grading

Answer 7

1: low proliferative potential
2: infiltrative but low proliferative activity
3: malignant w/ nuclear atypia
4: malignant, necrosis

Question 8

Radiation Tx has this serious potential complication

Answer 8

patients are more prone to other types of cancers

Question 9

Gliomas vs. Astrocytomas

Answer 9

same thing

Question 10

Pilocytic astrocytoma

Answer 10

grade I astrocytoma

Question 11

Rosenthal fibers are found in which type of astrocytoma?

Answer 11

pilocytic astrocytoma

Question 12

Targeted BRAF Tx possible in this tumor

Answer 12

pilocytic astrocytoma

Question 13

How does one visualize BRAF hybridizations?

Answer 13

FISH

Question 14

Is a BRAF-KIAA1549 fusion good or bad prognosis?

Answer 14

bad

Question 15

What is Grade 1 astrocytoma?

Answer 15

pilocytic astrocytoma

Question 16

What is Grade 2 astrocytoma?

Answer 16

diffuse astrocytoma

Question 17

Do diffuse astrocytomas typically become anaplastic?

Answer 17

yes

Question 18

Gemnistocytic subtype exists in this grade of astrocytoma

Answer 18

diffuse astrocytoma (2)

Question 19

What is Grade 3 astrocytoma?

Answer 19

anaplastic astrocytoma

Question 20

What is the GFAP protein?

Answer 20

glial fibrillary acidic protein

Question 21

What is the function of GFAP?

Answer 21

principle intermediate filament in astrocytes

Question 22

What is the pathological utility of GFAP?

Answer 22

one can stain for GFAP to stage

Question 23

GFAP is found in which stage of astrocytoma?

Answer 23

anaplastic astrocytoma (3)

Question 24

Grade 4 astrocytoma

Answer 24

glioblastoma multiforme

Question 25

What is a glioblastoma that crosses the midline called

Answer 25

butterfly

Question 26

What is the dead giveaway for glioblastoma?

Answer 26

necrosis

Question 27

Tumor that typically presents w/ seizures

Answer 27

oligodendrocytoma

Question 28

Which type of tumor are rosettes typically found?

Answer 28

ependymoma

Question 29

What are rosettes?

Answer 29

cells forming in a ring with fibrillary fibers in the middle that they secreted

Question 30

What is the dead giveaway for ependymomas?

Answer 30

rosettes

Question 31

Where do you find Pulmor-Wright rosettes?

Answer 31

medulloblastomas

Question 32

Where are medulloblastomas usually found?

Answer 32

posterior fossa of children

Question 33

This type of tumor may result in hearing loss

Answer 33

Schwannoma

Question 34

What is pseudopalisading necrosis?

Answer 34

palisading: perpendicular looks like cells are running away from necrosis to get a fresh blood supply