Coated Vesicles in Cellular Transport Processes Flashcards Preview

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Flashcards in Coated Vesicles in Cellular Transport Processes Deck (11):

what is an example of a coat on a vesicle?



Why are there different types of protein coats on vesicles?

Because the specific type of protein coat helps in the sorting of molecules that are fated for different destinations in the cell


What are clathrin coated vesicles involved in, in terms of origin and destination of the vesicle?

Clathrin coated vesicles are involved in the selective transport of proteins from the TGN to endosomes and in the endocytosis of receptor-ligand complexes from the plasma membrane


what are clathrin coated vesicles surrounded by?

two multimeric proteins - clathrin and adaptor protein


Why is using clathrin coated vesicles advantageous to the cell?

Because the unique shape of the clathrin proteins and the way they assemble to form clathrin coats provides the driving force that causes flat membranes to curve and form spherical vesicles


How is clathrin structured... what does it look like?

One clathrin triskelion is located at each vertex of the polygonal lattice

Each polypeptide leg extends along two edgesof the lattice, with the knee of the clathrin heavy chain located at an adjacent vertex


How do adaptor protein complexes come into play with clathrin coated vesicles?

AP complexes mediate the attachment of clathrin to proteins embedded in the plasma membrane 

Also sites for the regulation of clathrin assembly and disassembly



What are the factors that affect the ability of AP complexes to bind to clathrin?

pH, phosphorylation and dephosphorylation


What shape to clathrin proteins initially make?

What shape after more are incorportated?



Hexagon and Pentagon


What is the protein that is triggered by an accumulation of clathrin?

Dynamin- participates in the process

required for budding of the vesicle and coated pit construction