Coeliac Disease Flashcards Preview

Gastrointestinal Conditions > Coeliac Disease > Flashcards

Flashcards in Coeliac Disease Deck (14):
1

What is coeliac disease?

An immune-mediated, inflammatory disorder provoked by gluten in genetically susceptible individuals

2

Prevalence in UK of coeliac disease

1 in 100 (> if irish)

3

Pathogenesis of coeliac disease:

T-cell response to gluten in the small bowel causes villous atrophy and malabsorption

4

Coeliac associated HLA types:

HLA-DQ2 (95%)
HLA-DQ8 (5%)

5

Skin manifestation of coeliac disease:

Dermatitis Herpetiformis

Itchy, blistering rash

6

Risk factors for coeliac disease:

* FHx of coeliac
* Type 1 DM
* Down's syndrome
* Turner's syndrome
* AI Thyroid disease
* Addison's
* RA

7

Symptoms of coeliac disease:

* Stinking stools
* Steatorrhoea
* Abdominal pain
* Bloating
* N&V
* Aphthous mouth ulcers
* Fatigue
* Weakness
* Failure to thrive

8

Signs of coeliac disease

* Angular stomatitis
* Weight loss
* Osteomalacia
* Dermatitis herpetiformis

9

Differential diagnosis of coeliac disease

* IBS
* Other food intolerance
* IBD
* Other forms of colitis
* Other causes malnutrition

10

Antibodies screened for in coeliac disease:

Anti-transglutaminase (an IgA)

11

Ix in coeliac disease:

1. Bloods: FBC (anaemia, high RCDW dt. multifactorial anaemia, ID & folate/B12), Haematinics, LFTs (elevated transaminases), calcium

2. Antibodies: Anti-transglutaminase

3. Duodenal biopsy : If high suspicion. Whilst on gluten-containing diet

12

FBC picture in coeliac disease:

Anaemia

Increased RCDW dt. multifactorial anaemia

1. IDA (-> microcytosis)
2. Folate/B12 (-> Macrocytosis)

13

Management of coeliac disease:

Lifelong strict gluten-free diet.

Exclude:
* Wheat
* Barley
* Rye

14

Complications of coeliac disease:

* Dermatitis herpetiformis
* Anaemia
* Osteopenia/osteoporosis
* Hyposplenism
* GI T-cell lymphoma
* Increased risk of malignancy
* Ulcerative jejunitis
* Neuropathies
* Psychosocial dysfunction