Coeliac Disease

Question 1

Coeliac Disease =

Answer 1

small intestine is sensitive to Gliadin (found in wheat, barley, and Rye), therefore leading to difficulty in digesting food.

Question 2

Coeliac Disease Complications

Answer 2

GI T-cell lymphoma
Oesophageal Cancer
Osteoporosis
Colon Cancer
Anaemia
Small Bowel Lymphoma
Small Bowel Adenocarcinoma.

Question 3

Coeliac Disease Associated Conditions

Answer 3

Dermatitis Herpetiformis
PBC
Diabetes
Autoimmune Hepatitis
Increases risk of enteropathy-associated T Cell lymphoma
Iron, folate, and vitamin B12 deficiency
Suspect Coeliac Disease in all of those with diarrhoea + weight loss/anaemia.

Question 4

Coeliac Disease Symptoms:

Answer 4

Diarrhoea
Weight Loss
Stinking stools/Steatorrhoea
Fatigue
Failure to thrive (children)
Bloating
Nausea
Vomiting
Angular Stomatitis
Aphthous Ulcers
Osteomalacia

Question 5

Coeliac Disease Investigations:

Answer 5

(patient must eat gluten for 6 weeks before they are tested):
Distal Duodenal Biopsy (done at Endoscopy which shows villous atrophy)
Serology (Anti Endomysial IgA, Anti Tissue transglutaminase),
Hb decreased
B12 decreased
Ferritin decreased
RCDW increased.

Question 6

Coeliac Disease Treatment:

Answer 6

Life-long Gluten-free diet (also you can refer to a dietician)