Collagen & Related topics Flashcards Preview

Ortho Basic Science > Collagen & Related topics > Flashcards

Flashcards in Collagen & Related topics Deck (12)
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1
Q

What is ECM extracellular matrix?

A

non-cellular portion of tissue that provides structural support and affects the development of biochemical function of cells

2
Q

What is collagen?

A

triple-helix proteins that form most of fibrils in ECM

cosists od combinations of alpha-1,2,3 chains

3
Q

What are GAGs Glycosaminogylcans?

A

Structural polysacchrides in the ECM

composed of repeating disaccharide

4
Q

What is Hyaluronic acid?

A

non-sulfated GAG.

proteoglycans are linked to hyluronic acid to form giant molecules most excellent lubricators and/or shock absorbers

5
Q

where do we find Type I collagen?

A

Skin, tendon, bone, annulus of intervertebral disk

6
Q

where do we find Type II collagen?

A

Articular cartilage, vitreous humor, nucleus pulposus of intervertebral disk

7
Q

where do we find Type III collagen?

A

Skin, Muscle, Blood vessels

8
Q

where do we find Type IV collagen?

A

Together with Laminin form basement membrane scaffold

9
Q

where do we find Type IX collagen?

A

Articular Cartilage

10
Q

where do we find Type X collagen?

A

Articular cartilage, mineralization of cartilage in growth plate

11
Q

where do we find Type XI collagen?

A

Articular cartilage

12
Q

What is Laminin?

A

Important component of the basal lamina. Laminin and type IV collagen form network for the basement membrane scaffold.