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THERAPEUTICS III TEST 4 > colon cancer > Flashcards

Flashcards in colon cancer Deck (18):
1

what stage of colorectal cancer usually isn't curable

stage 4

2

for over 40 years what was the only drug that had any benefit for colon cancer

fluorouracil

3

what is the treatment for stage 1 cancer

surgery to remove polyps

4

what is the treatment for stage 2 colon cancer

consider:
1. capecitabine or fluorouracil and leukovorin
2. FOLFOX or CapeOx or FLOX with larger tumors

5

what is the preferred treatment for stage III colon cncer

FOLFOX (category 1) or CapeOx

6

what is in FOLFOX regimen

bolus Fluorouracil
leucovorin
continuous Fluorouracil
oxaliplatin

7

why is oxaliplatin not added to fluorouracil and leukovorin in patients with stage II colon cancer

no survival benefit has been shown to adding oxaliplatin

8

what should be added to 50FU or capecitabine in patients with stage III colon cancer

oxaloplatin

9

True false:
FOLFIRI is superior to 5-FU/LV for colon cancer

false

10

what is in FLOX regimen

bolus Fluorouracil
leucovorin
oxaliplatin

11

what is in FOLFIRI regimen

bolus Fluorouracil
leucovorin
continuous Fluorouracil
irinotecan

12

what is the MOA of leucovorin

stabilizes enzymes enhancing activity of fluorouracil

13

what causes EGFR inhibitor resistanse

KRAS mutation

14

what drugs are EGFR inhibitors

panitumumab
cetuximab

15

what drugs target vascular endothelial growth factor

bevacizumab
ziv-aflibercept
regorafenib

16

what is the oral prodrug of fluorouracil

capecitabine

17

what is the MOA of 5-FU and Capecitabine Associated Diarrhea

causes abnormal absorption and secretion of fluids and electrolytes

18

what can be given with irinotecan to decrease acute diarrhea

atropine