Colorectal carcinoma Flashcards Preview

Gastrointestinal Conditions > Colorectal carcinoma > Flashcards

Flashcards in Colorectal carcinoma Deck (16):
1

Sex preponderance of colorectal malignancy:

M>F

2

UK epidemiology of colorectal carcinoma:

3rd most common Ca in UK

2nd most common Ca death in UK

3

Most common type of colorectal Ca:

Adenocarcinoma

4

Risk Fx for colorectal Ca:

* Neoplastic polyps
* IBD
* FAP
* HNPCC
* Diet
Low fibre
High red/processed meat
* Alcohol
* Smoking
* Previous Ca

5

Symptoms of colorectal ca:

Depends on site

Left sided
* Blood/mucus PR
* Altered bowel habit
* Obstruction (25%)

Right sided
* Weight loss
* Anaemia
* Abdo pain
* Obstruction less likely

6

Colorectal carcinoma in which site is more likely to obstruct?

Left sided (distal)

7

Signs of colorectal carcinoma:

* Abdominal mass
* Perforation (peritonitic)
* Haemorrhage (Melaena, blood PR)
* Weight loss
* Anaemia

8

Differential diagnosis of colorectal carcinoma:

* IBD
* Paralytic ileus
* Small intestine diverticulosis

9

Investigations in colorectal carcinoma:

1. Bloods: FBC, LFTs, CEA

2. FOB

3. Endoscopy: Sigmoidoscopy/colonoscopy

4. Imaging: CT, liver MRI/USS

10

Tumour marker used to monitor disease activity and Rx efficacy in colorectal Ca:

Carcinoembryonic antigen (CEA)

11

Old and new staging systems of colorectal carcinoma:

Duke's (A-D)

TNM (now preferred)

12

Surgical management of colorectal carcinoma:

Surgical
1. Resection (depends on site)

e.g. right hemicolectomy for caecal, ascending/proximal transverse

2. Hartmann's procedure

Emergency Rx for obstruction, perforation, palliation

3. Endoscopic

Stenting - obstruction, palliation

Microsurgery - Rectal disease

13

Medical management of colorectal Ca:

Radiotherapy
Mainly for palliation
Post-op for rectal tumours with high recurrence risk

Chemotherapy
FOLFOX regimen

14

Complications of colorectal Ca:

* Obstruction
* Perforation
* Metastasis

15

Screening for colorectal carcinoma:

Aged 60-74

Every 2 years

FOB test

Referral for endoscopic Ix if +

16

Pharmacological prevention of colorectal Ca

Aspirin 75mg OD