Common Viral Pathogens II Flashcards Preview

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Flashcards in Common Viral Pathogens II Deck (18):
1

Influenza

Basic Structures, important proteins, and roles in pathogenesis

51,000 deaths a year

RNA virus, segmented genome
Lipid Envelope
Hemagglutinin and nueraminidase (H and N) surface proteins
Type A causes epidemics

2

RSV
Basic Structures, important proteins, and roles in pathogenesis

ssRNA non segmented, 2 subtypes A and B, can drift, A sucks more,
Two proteins, F (*fusion) and G (binding)

3

Ebola
Basic Structures, important proteins, and roles in pathogenesis

Filovirus, enveloped neg RNA, 7 structural proteins, 2 non sturctural
Polyploid virions (strung together)

4

Flu

How to cause disease

1-3 day incubation
Fever, chills, myalgia, headache and cough

5

RSV
How to cause disease

Common cause of bronchiolitis, targets young children
Conjunctivae and nasopharynx
3-5 incubation
Constriction of smoooth muscles

6

Ebola
How to cause disease

Mucosal surfaces, very low ID50, infects phagocytic cells initially, fast replication, induced cytokine storm

Leads to necrosis, fluid leakage, shock, and organ failure

7

Flu
Transmission and prevention

Respiratory (air droplets)
Treatment: matric protein inhibitors or neuraminidase inhibitors

8

RSV
Transmission and Prevention

Respiratory droplets

Wash your hands!

9

EBola
Transmission and Prevention

Body fluids
Dont' touch body fluids

10

Flu

Vaccine strats

Inactivated influenza vaccine (IIV) and live attenuated influenza vaccine (LAIV)
All persons older than 6 without contraindication
High risks are targetted

11

RSV
Vaccine

Respigam, a month IM injection of human pooled antibody, expensive.

12

Ebola
Vaccine

Once infected and survive, you get immune,

13

Antigenic Shift

When an type a influenza is introduced to a human population with a completely novel H and/or N

14

Antigenic Drift

Gradual change in a virus that occures through a slow series of mutations in H and N

15

Origine, epidemiology and morbidity/mortality of h1n1

Swine human and bird origins
Started in mexico
High in children and young adults

16

H5Ni
Geographic occurance and Public health importance

Bird populations which can cause severe disease, starting in china and SE asia
we're scared its too similary to the 1918 flu outbreak

17

Necessary genes in influenza to cause a pandemic

H and N, when new, and mixed in pis, can cause epidemic

18

Stages of pandemic

Emergence of new flu subtype, virus must infect humans and cause illness, must be able to sustain h to h transmission