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Flashcards in Complex Genetic Disorders Deck (7):
1

What are the three types of obesity?

Syndromic, Monogenic and Common

2

What is syndromic obesity commonly accompanied by?

Mental Retardation
Dysmorphic features

3

Describe the action of leptin.

Leptin is produced by adipocytes and travels to the brain to let the brain know how much fat is stored in the adipose cells and thus regulates feeding

4

What are some features of leptin deficiency?

Low thyroid function
Immune problems
Incomplete/lack of puberty

5

What is the treatment for leptin deficiency?

Recombinant leptin

6

Name some genes that cause monogenic obesity.

POMC
PCSK1
MC4R
MRAP2

7

What are Genome Wide Association Studies used for in relation to obesity?

To identify single nucleotide polymorphisms that are associated with obesity e.g. FTO