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Flashcards in Contraceptives Deck (32)
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1

Ethinyl Estradiol & Mestranol MOA

Estrogen; Ethinyl groups greatly decrease hepatic metabolism; often used in oral contraceptive

2

Ethinyl Estradiol & Mestranol Tox (in combo pill)

Estrogen component responsible for breast enlargement, increased excitability

3

Ethinyl Estradiol & Mestranol uses

MC used as combo of estrogen/progestin for oral contraceptive; also in tx of prostate tumors

4

Progestin Drugs

Norethindrone, norgestrel, levonorgestrel

5

Progestin MOA

Progestin; Impairs sperm transport by thickening the cervical mucus, decreases motility of ovules in oviduct, & alters endometrium to impair implantation

6

Progestin Tox (in combo pill)

Progestin component responsible for acne & wt gain

7

What protein is progestin bound to in blood

Transcortin

8

What protein is estrogen bound to in blood

70% bound to SHBG

9

Which estrogen receptor is found in female genital tract

ER-alpha

10

which estrogen receptor is found in prostate and ovary

ER-beta

11

DDI of OCs

Failure w/ Abx, Rifampin, anti-HIV, anti-convulsants, St. John's wort

12

Which classes of drugs can be used for tx of endometrial cancer

progestin and anti-estrogens

13

which progestin is used in emergency contraceptive

levonorgestrel (2 doses 12 hours apart)

14

Mifepristone MOA

Anti-Progestin; Blocks binding of progesterone to its own receptor

15

Mifepristone uses

Uses: approved by the FDA for termination of pregnancy

16

Onapristone MOA

Anti-Progestin; Blocks binding of progesterone to its own receptor; More pure antagonist than Mifepristone

17

Clomiphene MOA

Anti-Estrogen; SERM w/ antagonistic action in all tissue- binds to ER-alpha & ER-beta: acts on hypothalamus blocking feedback inhibition thus stimulating GnRH release increasing LH/FSH and thus ovulation

18

Copper IUD MOA

copper is spermicidal

19

Copper IUD Tox

Copper may cause cramping; high initial cause

20

Is fertility quickly restored after use with copper containing IUD

Yes

21

how long is a copper IUD useful for? additional uses other than contraceptive?

Effective 15-20 yrs but FDA recommends 10 yrs; FDA approved for dysmenorrhea

22

Androgen (4)

Danazol, Testosterone cypionate, Testosterone transdermal patch, Fluoxymesterone

23

Non patch androgen Tox

Dose-related; virilizing effects on females, feminizing effects in males, suppression of LH & FSH; Decreased HDL, Increased LDL

24

patch androgen tox

Dose-related; virilizing effects on females, feminizing effects in males, suppression of LH & FSH; Decreased HDL, Increased LDL
AND
patch can cause tearing of skin

25

cypoterone acetate MOA

Androgen Receptor Antagonist; Competes w/ DHT for androgen receptor preventing translocation into nucleus

26

Vaginal contraceptive ring MOA

Inserted intravaginally by patient for 3 weeks, one week off; Delivers ethinyl estradiol & progestin

27

vaginal contraceptive ring Tox

h/a, discomfort, vaginal discharge

28

vaginal contraceptive ring PK

Not effective until in place for 7 days; Rapid return to fertility upon removal

29

testosterone cypionate PK

IM & LA

30

Fluoxymesterone PK

oral & SA