Flashcards in Control of BP Deck (27):
Sustained increase in BP
What is normal Range of BP?
90/60 to 120/80
BP range for Stage 1, 2 and Severe hypertension?
over 180 systolic or 110 diastolic
What is primary Hypertension?
The cause is unknown
What is Secondary Hypertension?
Caused by underlying condition
What is responsible for the short, acute control of BP?
What are the 2 responses of the Baroreceptor reflux?
-Adjust ANS to alter CO
-Adjust sympathetic drive to alter TPR
What are the 4 Medium and long term controllers of BP?
1. RAAS system
4. Atrial Natriuretic Peptide
Where is Renin Released from?
granular cells of the JGA in the afferent arterioles
What increases Renin Release ?
Reduced Na+ delivery
Reduced perfusion pressure - baroreceptors in afferent arterioles.
Describe RAAS cascade
Renin activates Angiotensinogen to ANG 1
ACE converts ANG 1 to ANG 2
What does ANG 2 do ?
stimulates Na+ Reabsorption
Aldosterone release from adrenal cortex
Which is the main receptor for ANG 2?
ANG 1 receptor .
ANG 2 is a side receptor
What other function does ACE have ?
Converts Bradykinin to peptide fragments
What does Aldosterone do?
Na+ reabsorption and removes K+
Activates of Apical Na+ and K+ Channels
What is a side effect of ACE inhibitors?
Bradykinin build up leads to dry cough
What does the SNS do?
Reduce renal Blood flow
Na/K ATPase in PCT
What does ADH do?
Increase water retention in collecting duct
what does atrial Natriuretic Peptide do ?
Vasodilation of afferent Art
Inhibits Na+ reabsorption
Atrial is release by what and where?
Stretching of the atrium - Myocytes
What other chemicals are more clinically important ?
Prostaglandins- buffer for RAAS, Vasodilator
Dopamine- formed from L-Dopa in kidneys
What diseases can cause secondary hypertension ?
What is Conn's Syndrome?
Aldosterone secreting adenoma - seen by hypokalaemia
What is Cushing's Syndrome ?
Excess cortisol - too much steroids
What is tumour of the adrenal medulla ?
secrets NA and A