Control of BP Flashcards Preview

CVS > Control of BP > Flashcards

Flashcards in Control of BP Deck (27):
1

Define Hypertension

Sustained increase in BP

2

What is normal Range of BP?

90/60 to 120/80

3

BP range for Stage 1, 2 and Severe hypertension?

over 140/90
over 160/100
over 180 systolic or 110 diastolic

4

What is primary Hypertension?

The cause is unknown

5

What is Secondary Hypertension?

Caused by underlying condition

6

BP=

CO*TPR
SV*HR*TPR

7

What is responsible for the short, acute control of BP?

Baroreceptor reflex
Threshold reset

8

What are the 2 responses of the Baroreceptor reflux?

-Adjust ANS to alter CO
-Adjust sympathetic drive to alter TPR

9

What are the 4 Medium and long term controllers of BP?

1. RAAS system
2. SNS
3. ADH
4. Atrial Natriuretic Peptide

10

Where is Renin Released from?

granular cells of the JGA in the afferent arterioles

11

What increases Renin Release ?

Reduced Na+ delivery
SNS Drive
Reduced perfusion pressure - baroreceptors in afferent arterioles.

12

Describe RAAS cascade

Renin activates Angiotensinogen to ANG 1
ACE converts ANG 1 to ANG 2

13

What does ANG 2 do ?

Vasoconstrictors
stimulates Na+ Reabsorption
Aldosterone release from adrenal cortex

14

Which is the main receptor for ANG 2?

ANG 1 receptor .
ANG 2 is a side receptor

15

What other function does ACE have ?

Converts Bradykinin to peptide fragments

16

What does Aldosterone do?

Na+ reabsorption and removes K+
Activates of Apical Na+ and K+ Channels
ENaC
Na/K/ATPase

17

What is a side effect of ACE inhibitors?

Bradykinin build up leads to dry cough

18

What does the SNS do?

Reduce renal Blood flow
Stimulates Renin
Na/K ATPase in PCT

19

What does ADH do?

Raise BP
Increase water retention in collecting duct
Na+ Reabsorption

20

what does atrial Natriuretic Peptide do ?

Lowers BP
Vasodilation of afferent Art
Inhibits Na+ reabsorption

21

Atrial is release by what and where?

Stretching of the atrium - Myocytes

22

What other chemicals are more clinically important ?

Prostaglandins- buffer for RAAS, Vasodilator
Dopamine- formed from L-Dopa in kidneys

23

What diseases can cause secondary hypertension ?

Renovascular diseases
Renal Parenchymal
Adrenal Causes

24

What is Conn's Syndrome?

Aldosterone secreting adenoma - seen by hypokalaemia

25

What is Cushing's Syndrome ?

Excess cortisol - too much steroids

26

What is tumour of the adrenal medulla ?

Phaeochromocytoma
secrets NA and A

27

What is the ACD(B) Treatment of hypertension ?

ACE inhibitors
L-Type Ca2+ channel blockers- A1 antagonists
Diuretics
Beta blockers - only with another condition