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Clinical Medicine- Pulmonary > COPD > Flashcards

Flashcards in COPD Deck (25):
1

This disease is caused by 1 or combination of these disorders which causes airway ________ and ________?

Emphysema, asthma, chronic bronchitis. Limitations and obstructions

2

All structures of the acinar are affected by this type of emphysema and is caused by?

Panacinar, alpha-1 antitrypsin deficiency

3

This type of emphysema affects respiratory bronchioles is is caused by?

Centriacinar, cigarette smoking, coal mining

4

The decrease in expiratory airflow in COPD is caused by?

elasticity of the lungs

5

Is defined by productive cough that last 3 months and occurs two years in a row?

Chronic bronchitis

6

These are two hallmarks of COPD?

inflammation and partially or non-reversible airflow obstruction

7

Clinical manifestations of COPD?

Dyspnea, cough, sputum production, weight gain or loss, decreased sexual activity, cough syncope, depression or anxiety

8

Single best indicator of COPD?

decline in FEV1

9

Physical exam findings of severe COPD?

Barrel chest, prolonged expiratory phase, accessory muscle recruitment, wheezing and rhonchi, cyanosis

10

Diagnostic testing for COPD?

pulse ox, chest xray, PFT, CT of lungs

11

FEV1/FVC indicator of COPD?

12

CXR findings for COPD?

Hyperinflation, flattened diaphragms, decreased vascular markings

13

Options for smoking cessation?

Varenicline (Chantix), wellbutrin, nortriptyline, nicoderm CQ, habitrol patches

14

Dosing for Varenicline (Chantix)

Initial dose: 0.5mg x 3 days, 0.5mg BID x 4 days, 1g BID x 11 weeks

15

Side effects of Varenicline

GI distress, headache, vivid dreams, suicidal thoughts and depression

16

Treatment of stable COPD

bronchodilators (beta agonist, anticholinergics) ICS

17

Short acting bronchodilators (beta agonist)

Albuterol and levalbuterol

18

Anticholinergics

Ipratropium (atrovent) short acting. Titotropium (spiriva) or Aclinidium (tudorza) long acting

19

long acting beta-2 agonist

Salmeterol (Serevent), Formoterol (foradil)

20

ICS are used with these medications and should not be taken as?

LABA or anticholinergic. Should not be taken as monotherapy

21

ICS

Beclomethasone (Qvar), budesonide (pilmicort), fluticasone (flovent), mometasone (Asmanex)

22

Combination ICS + LABA?

Budesonide + Formoterol (Symbicort), Flucticasone + Salmeterol (Advair), Vilanterol + Fluticasone (breo ellipta)

23

This medication can be added onto triple combination thereapy for refractory disease?

low dose theophylline. not use alot in the US. levels need monitored due to toxicity

24

Oral medication that decreased airway inflammation?

PDE-4 inhibitors (phosphodiesterase 4 inhibitor)

25

Percent on PFT that indicates COPD?

70%