Flashcards in COPD Deck (65)
Is it true that COPD is mainly underdiagnosed?
What percentage of people diagnosed with COPD are smokers?
What genes play a role in the etiology of COPD?
TNF, surfactant, proteases and antiproteases
Inherited mutation in alpha-1 _ gene leads to _ deficiency
True or false: Impairment of fetal development resulting in low birthweight is a predisposing factor to COPD
True or false: Infants who develop bronchopulmonary dysplasia are susceptible to developing COPD
What are the 3 COPD phenotypes?
Chronic bronchitis, emphysema, bronchiectasis
What phenotype is characterized by airway inflammation and obstruction of the major and small airways?
What phenotype has a productive cough for at least 3 consecutive months over 2 years to be diagnosed?
What phenotype is characterized by loss of lung elasticity and abnormal enlargement of the airspaces distal to the terminal bronchioles with destruction of the alveolar walls and capillary beds?
What is bronchiectasis?
Permanent dilation of the bronchi and bronchioles due to destruction of the muscle and elastic supporting tissue
T/F: Sinitus is a commonly seen in past medical Hx of patients with COPD
T/F: acute eosinophilic inflammation is seen within the bronchioles in COPD
False, this type of inflammation is seen in asthma
What is the chronic obstruction of the airways due to inflammation and irreversibility characteristics of?
T/F: The pathologic changes of COPD include squamous metaplasia of epithelium, parenchymal destruction, mucus gland metaplasia and enlargement
T/F: The pathologic changes of COPD include fragile epithelium, thickening of basement membrane, mucus gland metaplasia and enlargement
False; this is true of asthma
What causes the loss of lung elastic recoil in COPD?
The proteases mediate degradation of connective tissue elements in the lungs
_fibrosis is caused by the imbalance of the lungs repair and defense mechanisms
What is the key factor in developing irreversible airflow limitation seen in COPD?
Fibrosis of the small airways leading to remodeling
Inflammation and _ injury play a role in mucus hypersecretion
Increased tone n airway SM due to _ of the bronchi with _ due to persistent _
hyperactivity, bronchoconstriction, inflammation
"blue bloaters" is a term used for_
Which phenotype would you expect to see cyanosis and edema in the abdomen and legs?
When would you expect to see ciliary function impaired?
Why does the body increase RBC production in chronic bronchitis?
In hopes to try and oxygenate the blood but the blood just gets thicker increasing pulmonary pressure
What phenotype of COPD is known as "pink puffers"
The breakdown of _ in the alveolar septa and bronchial walls by _ is seen in _
elastin, proteases, emphysema
Alpha-1 antitrypsin deficiency is seen in _
Proteases are released from _, alveolar macrophages and other inflammatory cells