Cornoary Heart Disease Flashcards Preview

Year 2 Pharmacology > Cornoary Heart Disease > Flashcards

Flashcards in Cornoary Heart Disease Deck (15):
1

What is CHD?

narrowing of the arteries that supply the heart, due to fatty material called atheroma

2

What is angina?

crushing pain in chest that may radiate to arm, neck or jaw

3

How to nitrates work?

GTN - fast acting, sublingual tablet or spray, rapidly metabolised by the liver
-Vasodilator
-release of nitrogen oxide which increases cGMP in muscle cells causing them to relax
-reduces heart filling/contraction strength
-caution with hypertension and Viagra

4

What are the side effects of GTN?

throbbing headache (cerebral vasodilation)
dizziness (low bp)

5

What are statins?

Reduced amount of cholesterol in blood stream, block body from making cholesterol
HMG-CoA reductase is rate-limiting step in cholesterol synthesis (lipid-lowering)
Given to people with high cholesterol - prevents atheroma

6

What are side effects of statins?

GI upset
Abnormal liver tests
Muscle problems

7

What is the effect of GTN?

Increased heart rate

8

Which drug helps reduce cholesterol in the blood?

Simvastatin

9

HDL

Good cholesterol .. takes it away

10

LDL

Bad cholesterol .. transports cholesterol to cell and tissue

11

Drugs used to reduce heart rate

beta blockers

12

Drugs used to reduce filling/ contraction strength

Nitrovasodilators

13

Drugs used to reduce arterial resistance

Blood pressure lowering drugs

14

Drugs used to prevent atheroma formation

Cholesterol lowering drugs (eg statins)

15

Drugs used to decrease clotting

Anti platelet drugs