Flashcards in Cornoary Heart Disease Deck (15):
What is CHD?
narrowing of the arteries that supply the heart, due to fatty material called atheroma
What is angina?
crushing pain in chest that may radiate to arm, neck or jaw
How to nitrates work?
GTN - fast acting, sublingual tablet or spray, rapidly metabolised by the liver
-release of nitrogen oxide which increases cGMP in muscle cells causing them to relax
-reduces heart filling/contraction strength
-caution with hypertension and Viagra
What are the side effects of GTN?
throbbing headache (cerebral vasodilation)
dizziness (low bp)
What are statins?
Reduced amount of cholesterol in blood stream, block body from making cholesterol
HMG-CoA reductase is rate-limiting step in cholesterol synthesis (lipid-lowering)
Given to people with high cholesterol - prevents atheroma
What are side effects of statins?
Abnormal liver tests
What is the effect of GTN?
Increased heart rate
Which drug helps reduce cholesterol in the blood?
Good cholesterol .. takes it away
Bad cholesterol .. transports cholesterol to cell and tissue
Drugs used to reduce heart rate
Drugs used to reduce filling/ contraction strength
Drugs used to reduce arterial resistance
Blood pressure lowering drugs
Drugs used to prevent atheroma formation
Cholesterol lowering drugs (eg statins)