CORTEXT Flashcards
What is the most abundant component of cartilage extracellular matrix
water
malignant swelling
Systemic upset with weight loss and fatigue
Larger lesions (>5cm)
An irregular surface
A mostly lucent lesion, with a patchy sclerosis, found within the metaphyseal region of long bones.
endochondroma
A lucent, multi-loculated cyst found within the medulla of many different bones, often with associated cortical expansion
anuerysmal bone cyts
A bony spur, originating the in metaphyseal regions of long bones, growing away from the epiphysis.
osteochondroma
a number of ? will congregate and begin to ‘drill’ into the bone,
osteoclasts
which cells lay down new bon e
osteoblasts
do myofibrils run across the fibre
no
they lie lognitutidinally
what is avascular necrosis a secondary cause of
osteoarthritis
primary malignant tumours which commonly metastasise to bone
Breast carcinoma
Prostate carcinoma
Lung carcinoma
Renal cell carcinoma
Thyroid adenocarcinoma
osteoclasts
bone resorption
osteoblasts
bone forming cells
Osteoprogenitor cells:
located on bone surfaces, for example under the periosteum, these cells serve as a pool of reserve osteoblasts
osteochondroma
dont usualy cause problems but can cause pain
commonest benign bone tumour
what are muscle fibres grouped into
fasiscles
connective tissue ofmuscle
surrounds the muscle as a whole is called the epimysium
the connective tissue around a single fascicle is the perimysium
connetive tissue around a single muscle fibre is the endomysium
in sle when disease is active do complement levels rise
no
levels are low when sle is active
first test to do in suspected sle
urinalysis
to screen for renal diseade
A thrombotic event in a patient with antiphospholipid syndrome is an indication for life-long anti-coagulation
true or false
true
spondyloarthropathies
Ankylosing spondylitis, psoriatic arthritis and reactive arthritis
subchodnral scleoris s
thickening of bone seen in oA
is RA hypo or hyper trophic
hypotrophic whereas OA is hyper
joint aspirate in reactive arthritis
The joint aspirate in reactive arthritis is usually sterile- if it was positive for organisms on gram stain or culture then it is a septic arthritis
extraarticular manifestations in spondyloarthropathies
Achilles tendonitis, aortic valve incompetence, uveitis and dactylitis
