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Flashcards in corticosteroids Deck (30):
1

short-medium acting glucocorticoids

Hydrocortisone (cortisol) (Cortaid®)
Prednisone Intensol
Methylprednisolone (Medrol)

2

intermediate-acting glucocorticoids
MORE anti-inflamm. potency
LESS mincort potency (vs short acting)

Triamcinolone(Nasacort)

3

long-acting glucocorticoids

Dexamethasone (Baycadron)

4

glucocorticoid synthesis inhibitor and antagonists

Metyrapone (Metopirone)
Ketoconazole (Nizoral) (*antifungal)

5

glucocorticoid and mineralocorticoid antagonists

Spironolactone (Aldactone)

6

glucocorticoid, mineralocorticoid, androgen, progesterone and estrogen agonist

Cosyntropin (Cortrosyn®)

7

mineralocorticoids agonists

Fludrocortisone

8

17-hydroxysteroids (17-OH)

steroid metabolite that can be measured in urine

9

if have mineral corticoid activity

promote Na reabsorption in renal distal tubules, inc. excretion potassium and hydrogen ions

10

allergy tx

prednisone
methylprednisolone
triamcinolone
dexamethasone

11

cerebral edema tx

prednisone

12

bacterial meningitis tx

dexamethasone

13

hematological disorders tx

prednisone, triamcinolone, dexamethasone

14

collagen disorders tx

prednisone, methylprednisolone, triamcinolone,
dexamethasone.

15

hepatic disease tx

prednisolone
(+ azathioprine)

16

renal disease tx

methylprednisolone

17

respiratory tx

prednisone
betamethasone
dexamethasone

18

learn adverse effects

!!

19

GI SEs

decrease the mucus protection, inc. acid, ulcers
*synergisim with NSAIDS*-->inc. GI events

20

edema SEs

fluid retention w/ heart/kidney disease, Na restriction

21

carb/lipid metab SEs

hyperglycemia, aggravate DM

22

hypokalemia SE

hypokalemia, met alkalosis, asthenia, paraylsis, arrythmias-->cardiac arrest

23

hypophosphatemia SE

low levels blood phosphate

24

osteonecrosis SE

femoral head, humeral head, femoral condyles, tibial plateau, talus, capitulum
-fat embolism, hypercoag., inc. IOstP, fat swelling
-joint pain 1st

25

negative N balance

excessive breakdown, eat high protein diet to overcome

26

CNS edema

behavior/personality changes
euphoria, insomnia, inc. appetite, nervousness, sleep diet, psychosis, paranoia

27

growth suppression

children : should avoid using!!

28

myopathy

loss of muscle mass, UE/LE
reversible
9a fluorinated steroids (i.e. triamcinolone)

29

skin and soft tissue

purpura, skin thinning, SCC, BCC
acne, alopecia, hypertrichosis, striae
cushingoid features

30

cushingoid features

truncal obesity, buffalo hump, moon face, weight gain