Corynebacterium Diftarie Flashcards

1
Q

Características

A

Bacilos pleomorfos
No forman esporas
Se divide en 4 biotipos

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2
Q

Principal factor de virulencia

A

Toxina diftérica

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3
Q

Características toxina diftérica

A

-Toxina A-B codificada por el gen tox
-Se une al factor de crecimiento epidermico de unión a la heparina
-Inhibe la síntesis proteica al inactivar el factor de elongación

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4
Q

Reservorio

A

SOLO humano
Portadores asx

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5
Q

Transmisión

A

de manera directa

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6
Q

Cuadro clínico

A
  1. Difteria respiratoria
  2. Difteria cutánea
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7
Q

Difteria respiratoria

A

-Faringitis pseudo membranosa - se desprenden
-Pueden invadir laringe
-Sangrado al desprenderse
-1-2 semanas después: miocarditis y neuropatia

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8
Q

Difteria cutánea

A

Úlceras crónicas

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9
Q

Erradicada

A

En 1991

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10
Q

Vacuna en humanos

A

Toxoide diftérico

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11
Q

Persona puede ser portadora de la bacteria?

A

Si pero no causa la enfermedad

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12
Q

Tx

A

-Antirotoxina antidifterica - inmonuglobulina en vacuna
-Penicilina
-Protección de la vía aérea
-Muy contagiosa pero no genera inmunidad

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