Flashcards in CP17 - Abnormalities of Growth, Differentiation and Morphogenesis Deck (10):
what is adaptations of cells?
reversible changes in cells usually due to changes in environment or demand
what is the difference between cellular adaptation for physiological and pathological adaptation
physiological - responding to normal changes in physiology or demannd
pathological - responding to disease related changes
what else can undergo hypertrophy and hyperplasia except the cell itself?
subcellular organelles - eg smooth ER hypertrophy in hepatocytes with barbiturates to increase metabolism of other drugs
what is gynaecomastia
enlargement of men's breast usually due to hormonal imbalance
what are some examples of physiological atrophy?
embryogenesis, uterus after pregnancy or menopause
what are some examples for pathological atrophy
Decreased workload (disuse atrophy)
Loss of innervation (denervation atrophy)
Diminished blood supply
Inadequate nutrition (eg cachexia)
Loss of endocrine stimulation
what is involution
physiological atrophy by apoptosis
what is metaplasia
transformation of one differentiated cell type into another
what are some examples of metaplasia
pseudostratified cilliated bronchial epithelium - to squamous epithelium after cigarette smoke