CP17 - Abnormalities of Growth, Differentiation and Morphogenesis Flashcards Preview

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Flashcards in CP17 - Abnormalities of Growth, Differentiation and Morphogenesis Deck (10):
1

what is adaptations of cells?

reversible changes in cells usually due to changes in environment or demand

2

what is the difference between cellular adaptation for physiological and pathological adaptation

physiological - responding to normal changes in physiology or demannd

pathological - responding to disease related changes

3

what else can undergo hypertrophy and hyperplasia except the cell itself?

subcellular organelles - eg smooth ER hypertrophy in hepatocytes with barbiturates to increase metabolism of other drugs

4

what is gynaecomastia

enlargement of men's breast usually due to hormonal imbalance

5

what are some examples of physiological atrophy?

embryogenesis, uterus after pregnancy or menopause

6

what are some examples for pathological atrophy

Decreased workload (disuse atrophy)
Loss of innervation (denervation atrophy)
Diminished blood supply
Inadequate nutrition (eg cachexia)
Loss of endocrine stimulation
Pressure

7

what is involution

physiological atrophy by apoptosis

8

what is metaplasia

transformation of one differentiated cell type into another

9

what are some examples of metaplasia

pseudostratified cilliated bronchial epithelium - to squamous epithelium after cigarette smoke

10

what is dysplasia

earliest morphological manifestation of multistage process of neoplasia - in-situ, non invasive