Crystal Arthopathy Flashcards
1
Q
What are crystal deposition diseases?
A
- deposition of mineralised material within joints and peri-articular tissue
2
Q
What causes hyperuricaemia?
A
- overproduction of uric acid
- malignancy
- severe exfoliative psoriasis
- drugs
- inborn errors of metabolism
- HGPRT deficiency
- under excretion of uric acid
- renal impairment
- hypertension
- hypothyroidism
- drugs
- exercise, dehydration, starvation
- lead poisoning
3
Q
What is the managment of gout?
A
Acute flare:
- NSAIDs
- colchicine
- steroids
Hyperuricaemia:
- xanthine oxidase inhibitor
- febuxostat
- uricosuric agents (e.g. sulphinpryazone)
- canakinumab
* treat if 2nd attack within 1 year
* prophylactically
4
Q
What causes pseudogout?
A
- iodiopathic
- familial
- metabolic
- trauma
- intercurrent illness
- elderly females
5
Q
What is the managment of pseudogout?
A
- NSAIDs
- I/A steroids
6
Q
What is polymyalgia rheumatica?
A
- sudden onset shoulder/pelvic girdle stiffness
- > 70 yrs
- F:M = 2:1
7
Q
What are the signs of polymyalgia rheumatica?
A
- anaemia
- weight loss, malaise, depression
- fever
- arthralgia, synovitis
- ESR > 45 (often 100)
8
Q
What is the treatment for polymyalgia rheumatica?
A
- prednisolone (15mg/day, initially)
- 18-24 month course
- bone prophylaxis
