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Flashcards in Crystal Arthropathies Deck (29):
1

What is the salt found in gout?

Monosodium urate monohydrate

2

What gender is more affected by gout?

Males

3

What are some risk factors for gout?

- Obesity
- Metabolic Syndrome
- Diet
- Thiazide Diuretics

4

Gout

- Supersaturation of uric acid
- Crystal formation which activate immune system
- Trigger complement cascade which
recruits neutrophils
- Phagocytosis by monocytes activates intracellular inflammasome

5

What is the most likely cause of gout, overproduction or under excretion?

Underexcretion

6

What are the 2 important enzymes on the urate synthesis pathway?

- Deaminase
- Xanthine Oxidase

7

Podagra

Typical pain of gout found in the big toe - acute involvement of 1st MTP

8

Calcium Pyrophosphate Deposition Disease is AKA....

Pseudogout

9

What are the joints most often involved in pseudo gout?

Knees and wrist

10

What population is pseudo gout seen in?

Older people

11

Chondrocalcinosis

Calcium crystal deposition in meniscus of the knee and triangular cartilage of the wrist

12

Milwaukee Shoulder

- Hydroxypatite associated destructive arthritis
- Elderly females with destruction of rotator cuff and glenohumeral joint

13

Polymyalgia Rheumatica

Autoimmue disorder that causes pain and stiffness in proximal joints and muscles
- Shoulders and hips, neck muscles can be affected

14

What disease is polymyalgia rheumatica associated with?

Giant Cell Arteritis

15

What gender is more affected by polymyalgia rheumatica?

Females

16

Fibromyalgia

Chronic widespread pain with 11 or more tender points - more likely in women

17

Tenosynovial Giant Cell Tumor

Most common benign neoplasm of the synovium and is associated with translocation fusing the promoter of the collagen 6A3 gene to the coding sequence of M-CSF - can be localized or diffuse

18

Synovial Chondromatosis

Multiple nodules of hyalgine cartilage within subsynovial connective tissue with the knee most commonly affected - benign

19

What are foods to avoid for gout patients?

- Red meat
- Beer
- Shellfish
- Beans

20

Allopurinol MOA

Xanthine oxidase inhibitor - decreases the uric acid generated

21

What is poodagra indicative of?

Gout

22

What is positive birefringence indicative of?

CPPD - pseudogout

23

What is negative birefringence indicative of?

Gout

24

What biologic anti-inflammatory can be used in pseudo gout?

Anti-IL1

25

Where can hydroxyapatite also be found?

In the tendons

26

What is the treatment for polymyalgia rheumatica?

Corticosteroids

27

What is a major trigger/cause of fibromyalgia?

Lack of sleep - decreases pain tolerance

28

What is the joint most likely affected by Tenosynovial Giant Cell Tumor?

Knee

29

What is seen on histology of tenosynovial giant cell tumors?

Multiple hemosiderin-laden
macrophages, osteoclast-like giant cells

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