CT1 Flashcards
(82 cards)
TF CT has only structural role
F its dynamic and Biologically interactive function
Connective tissue was critical to the evolution of ——– organisms.
Connective tissue was critical to the evolution of multicellular organisms.
❂ Extracellular matrix (ECM) is the material outside of the cells and —– and ——borders.
❂ Extracellular matrix (ECM) is the material outside of the cells and epithelial and endothelial borders.
CT
cells plus the ECM
TF The ECM is an extension of the cell and participates PassivELY in cell function.
The ECM is an extension of the cell and participates ACTIVELY in cell function.
CT
Stabilize the physical structure of tissues
protein PG GP
CT
major protein of CT
elastin
Allowed emergence of efficient circulatory and respiratory systems
elastin
order the following Translation Transcription (tropoelastin and microfibril components) Fiber formation Secretion
Transcription (tropoelastin and microfibril components) Translation Secretion Fiber formation
igf1 , tgf beta
ELN increased
TNFα (bFGF) HB-EGF
Decrease ELN transcription
The product of the ELN gene is
The product of the ELN gene is tropoelastin
Tropoelastin
Tropoelastin is secreted into the ECM.
Cross-linking renders the elastin fiber highly insoluble.—–
Cross-linking renders the elastin fiber highly insoluble.
crosslinking of Tropoelastin
elastin fiber
ECM;
tropelastin + microfibrils
tf tropoelastin nevr binds to microfibrils
F they bind
lysyl oxidase
mediates cross linking
tf elastin molecules can expand and contract
T
TF Treatment with NaOH at high temperature solubilizes virtually all proteins and the insoluble elastin.
Treatment with NaOH at high temperature solubilizes virtually all proteins, but not the insoluble elastin.
Tf In vitro, there are enzymes known as elastases that can cleave the elastin fiber.
In vivo, there are enzymes known as elastases that can cleave the elastin fiber.
cutis laxa
elastin mut–> skin laxity
narrow aorta , heart failure
Supravalvular aortic stenosis
