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Flashcards in cutaneous neoplasms Deck (43):
1

mutation in seborrheic keratosis

FGF3

2

multiple sudden lesions that can possibly be paraneoplastic

seborrheic keratosis

3

round, exophytic, coinlike "stuck-on" lesions

seborrheic keratosis

4

monotonous sheets of small cells that resemble the basal cells of normal epidermis with variable pigment

seborrheic keratosis

5

less than 1 cm, tan-brown or red in color rough to the touch

actinic keratoses

6

cytologic atypia with hyperplasia of basal cells or atrophy and diffuse thinning of the epidermal surface.

actinic keratoses

7

lesions considered squamous cell carcinoma in situ

actinic keratosis with full thickness epiderimal atypia

8

dermis contains thickened blue-gray elastic fibers

actinic keratosis

9

present on sun-exposed skin

actinic keratosis

10

common tumor arising on sun-exposed surfaces in older people

sqaumous cell carcinoma

11

most common cause of sqaumous cell carcinoma

UV damage

12

mutation involved in sqaumous cell carcinoma

TP53 caused by UV, HRAS

13

sharpley defined, red scaling plaques advancing to nodular and ulcerative lesions

sqaumous cell carcinoma

14

highly atypical cells at all levels of the epidermis

sqaumous cell carcinoma

15

likelyhood of metastasis of sqaumous cell carcinoma tied to

thickness of lesion and degree of invasion into subQ tissue

16

associated with dysregulatio of hedgehog pathway

basal cell carcinoma

17

mutation in Basal cell carcinoma

PTCH

18

pearly papules often with priminent telangiectasia

basal cell carcinoma

19

two types of basal cell carcinoma

multifocal growth or nodular lesions

20

nest of basaloid cells infiltrating fibrotic stroma

BCC

21

% of BCC pts who develop another tumor in 5 years

40%

22

skin cancer with very rare metastasis

BCC

23

hyperkeratosis and horn pseudocysts

seborrheic keratosis

24

spontaneous resolution without treatment

seborrheic keratosis

25

"volcano" looking lesion

keratoacanthoma

26

xeroderma pigmentosa a risk for

squamous cell carcinoma

27

peripheral pallisading

basal cell carcinoma

28

firm, tan to brown papule in the legs of a young-middle aged person

dermatofibroma

29

lesion that is factor XIIIa+

dermatofibroma

30

composed of fibroblass, histiocytes and dendrocytes

dermatofibroma

31

large, furm lumpy nodule on trunk or proximal extremities in young to middle aged adult

dermatofibrosarcoma protunerans

32

proliferation of monomorpheois spindle cells wih honeycomb pattern of fat entrapment

dermatofibrosarcoma protunerans

33

pink to skin colored papules , pustles and vesicles in kids

langerhans cell histiocytosis

34

can have osetolytic lesions

langerhans cell histiocytosis

35

bean shaped nuclei wih irreular contours

langerhans cell histiocytosis

36

expresses CD34

dermatofibrosarcoma protunerans

37

express s-100+ and CD1a+

langerhans cell histiocytosis

38

tennis raquet shaped birbeck granule

langerhans cell histiocytosis

39

poor prognosis mastocytois

systemic

40

mastocytosis usually seen in kids

urticaria pigmentosa

41

round to oval, red/brown, non scaling papules and plaques

mastocytosis

42

rubbing causes erythema and edema

mastocytosis

43

expresses CD117

mastocytosis