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Flashcards in CVM week 10 Deck (39)
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What is the necrotic core made up of?

Acellular, lipid rich core including cellular debris from foam cells, endothelial cells and smooth muscle cells


What are the predominant factors that affect the stability of an atherosclerotic plaque?

Cell composition and ratio of ECM to lipid content


What would a unstable plaque be like?

Thin fibrous cap, large lipid pool,many inflammatory cells, little collagen, large number of macrophages and a small number of smooth muscle cells


What would a stable plaque be like?

Small lipid pool, thick fibrous cap, preserved lumen


Are stable or unstable plaques more likely to rupture?



List some measures that may stabilise an atherosclerotic plaque?

Decreased LDL, increased HDL, decreased angiotensin II, decreased insulin resistance, decreased oxidative stress, decreased blood pressure


Describe stage 3: plaque disruption ?

Rupture or erosion of the plaques fibrous cap


Where does the rupture most commonly occur in the plaque?

At the shoulder cap of the plaque


How does rupture of the plaque lead to thrombosis?

Physical disruption of the atherosclerotic plaque - causes arterial thrombosis as blood coagulant factors contact thrombogenic collagen found in the arterial extracellular matrix and tissue factor produced by macrophage-derived foam cells in the lipid core of lesions.