Cytokines Flashcards Preview

Step 1 > Cytokines > Flashcards

Flashcards in Cytokines Deck (25):
1

waht 6 cytokines produced by T cell

1. IL-2
2. IL-3
3. IL-4
4. IL-5
5. IL-10
6. INF-gamma

2

5 cytokines released by macrophages

1. IL-1
2. IL-6
3. TNF-alpha
4. IL-8
5. IL-12

3

3 functions of INF-alpha and INF-beta

1. inhibit cellular protein synthesis
2. encourage activation of a ribonuclease that degrades viral mRNA
3. activates NK cells

4

2 functions of INF-gamma

1. stimulates macrophages
2. increases MHC I and MHC II expression in all cells

5

cause fever

IL-1

6

fever and production of acute phase reactants in liver

IL-6

7

3 substances responsible for neutrophil chemotaxis

1. TNF-alpha
2. C5a
3. LTB4

8

proliferation of helper T cells and cytotoxic T cells, also activates NK cells

IL-2

9

stimulates B cell growth and differentiation (2)

1. IL-4
2. IL-5

10

stimulates IgA production and stim eosiniphils

IL-5

11

stimulates IgE and IgG production

IL-4

*also stimulates B cell proliferation and differentiation

12

inhibits macrophages and inhibits Th1 cell differentiation

IL-10

*produced by Th2 and Treg

13

activates macrophages

INF-gamma

14

supports growth and differentiation of bone marrow cells

IL-3

15

induces Th1 differentiation and activates NK cells

IL-12

16

produced by Th1 cells

1. IL-2
2. INF-gamma

17

produced by Th2 cells

1. IL-2
2. IL-4
3. IL-5
4. IL-10

18

inhibits Th2 differentiation

INF-gamma

19

mnemonic for IL-1 through IL-5

"HOT T-Bone stEAk"

IL-1 = hot (pyrogen)
IL-2 = T cell prolif
IL-3 = Bone marrow stim
IL-4 = IgE production (and IgE)
IL-5 = stimulates IgA production (and act. eosinophils)

*also "clean up on aisle 8"--> IL-8 attracts neutrophils to clear infection

20

drug that is IL-2 analogue, used for renal cell carcinoma and metastatic melanoma

Aldesleukin

21

function of Filgrastim and Sargramostin

stimulate bone marrow production (GM-CSF analogues)

22

alpha-interferon drug indications (4)

1. Hep B and C
2. Kaposi's sarcoma
3. Leukemia (including Hairy cell)
4. genital warts
5. malignant melanoma

23

beta-interferon drug use (1)

multiple sclerosis

24

gamma interferon drug use (what dz)

NADPH oxidase deficiency--> chronic granulomatous dz

25

drug that is analogue of IL-11; use?

Oprelvekin--> used to tx thrombocytopenia, also thrombopoietin is used

Decks in Step 1 Class (63):