Cytotoxic Drugs Flashcards Preview

Pharmacology > Cytotoxic Drugs > Flashcards

Flashcards in Cytotoxic Drugs Deck (11):
0

FUFA - 5-fluorouracil and folinic acid

Antimetabolite
Colorectal cancer
Thymidylate synthase inhibitor

1

Bevacizumab

Monoclonal antibody
To vegf
Second line treatment

2

Cisplatin

Alkylating like agent
Binds to DNA, get bulky adducts
Part of platinum therapy
Early NSCLC

3

Etoposide

Topoisomerase inhibitor
Part of platinum therapy
Early NSCLC

4

Gemcitabine

Antimetabolite
Inhibit ribonucleotide reductase and DNA polymerase
Incorporates into DNA - chain termination
Part of platinum therapy
Early NSCLC

5

Docetaxel

Taxane
Prevents microtubule disassembly
Advanced NSCLC and breast cancer TAC regimen

6

Vinorelbine

Vinca alkaloid
Inhibits microtubule assembly
Advanced NSCLC

7

Erlotinib

Selective inhibitor of EGFR tyrosine kinase
Advanced NSCLC

8

Doxorubicin

Poison topoisomerase 2 by intercalating DNA by preventing in from unbinding from DNA
Breast Cancer TAC regimen

9

Cyclophosphamide

Alkylating agent
Nitrogen mustard
Breast cancer TAC regimen

10

Trastuzumab

Monoclonal antibody
Binds to extra cellular region of HER2 receptor
Breast cancer