Day 3: SGAS Flashcards Preview

Block 2.11: Psych > Day 3: SGAS > Flashcards

Flashcards in Day 3: SGAS Deck (12)
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1

Abilify

Aripiprazole

Characteristics:
Lower metabolic risk compared to other SGAs

Not as sedating

Formations:
ODT, IM injection and Long-acting injectable form

KNOW THEY ARE ALL D2 ANTAGONIST (with lower affinity than FGAS)

2

Sahris

Asenapine

Characteristics:
Lower metabolic risk compared to toher SGAs

Formations:
Sublingual tab only

KNOW THEY ARE ALL D2 ANTAGONIST (with lower affinity than FGAS)

3

Rexulti

Brexpiprazole

Characteristics:
Similar side effect profile to aripiprazole
Formations:
Tablet only

KNOW THEY ARE ALL D2 ANTAGONIST (with lower affinity than FGAS)

4

Vraylar

Cariprazine

Characteristics:
Very Tolerable side effects
Very long acting
CrCl<30 ml/min: avoid use

Formations:
Capsule only

KNOW THEY ARE ALL D2 ANTAGONIST (with lower affinity than FGAS)

5

Clozaril

Clozapine

Characteristics:
ONLY used in treatment resistance
ONLY antipsych med that is proven superior efficacy in treatment resistance
Not common with EPS
**shown to decrease suicidal ideation and aggression
REMS med
****MUST MONITOR absolute neutrophil count (ANC)
DC in patients if ANC <1000 in nonben pt, and
ANC<500 in BEN population
WATCH FOR arganulocytosis (ANC)
Drug levels are lower in cig smokers

BBB:
CV events
Fatalities due to myocarditis and cardiomyopathy
Seziures and neutropenia

Monitoring:

Months 1-6: weekly
Months 7-12: every other week
After 1 year: monthly

Formations:
Tab, ODT, suspension

KNOW THEY ARE ALL D2 ANTAGONIST (with lower affinity than FGAS)

6

Fanapt

Iloperidone

Characteristics:
Notorious for hypotension
Dosage adjustment if pt is poor metabolizer of CYP 2d6
Formations:
Tablet only

KNOW THEY ARE ALL D2 ANTAGONIST (with lower affinity than FGAS)

7

Latuda

Lurasidone

Characteristics:
Lowe metabolic risk compared to other SGAs

Formations:
Tablet only

KNOW THEY ARE ALL D2 ANTAGONIST (with lower affinity than FGAS)

8

Zyprexa

Olanzapine

Characteristics:
HIGHEST incidence of metabolic risk
Drug lvls may be lower in cigarette smoker (CYP 1a2)

Formations:
ODT, IM injection, LA injection

KNOW THEY ARE ALL D2 ANTAGONIST (with lower affinity than FGAS)

9

Invega

Paliperidone

Characteristics:
Active metabolite of risperidone
Lower EPS risk than risperidone
Can cause prolong Qt (avoid use in other meds that QT-prolong)

Formations:
Osmotic Controlled-release oral delivery system (OROS) tab
LA injection

KNOW THEY ARE ALL D2 ANTAGONIST (with lower affinity than FGAS)

10

Seroquel

Quetiapine

Characteristics:
Very sedating
Significant weight gain

Formations:
Tbalet form (IR and ER)

KNOW THEY ARE ALL D2 ANTAGONIST (with lower affinity than FGAS)

11

Risperdal

Risperidone

Characteristics:
Highest EPS risk among SGAs
Highest incidence of prolactin elevation among SGAs

Formations:
Tab, ODT, LA injection

KNOW THEY ARE ALL D2 ANTAGONIST (with lower affinity than FGAS)

12

Geodon

Ziprasidone

Characteristics:
Highest incidence of QT prolongation among SGAs
Low risk of metabolic side effects
Capsule must be taken with food

Formations:
Capsule, short-acting IM injection

KNOW THEY ARE ALL D2 ANTAGONIST (with lower affinity than FGAS)