Day 6, Lecture 2 (Aug 29): Genetics: Population genetics, Hardy-Weinberg equation Flashcards Preview

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Flashcards in Day 6, Lecture 2 (Aug 29): Genetics: Population genetics, Hardy-Weinberg equation Deck (19):
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Population genetics is 

The study of the frequency of alleles in populations, specifically population with diploid organisms

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In diploid organisms, the allele frequencies in the next generation tend to be similar/identical if the 

  • population is large, mating is random, and if there is no selection
    • this is named Hardy-Weinberg equilibrium

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Use of Hardy Weinberg

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Practical applications of the Hardy-Weinberg Equation/Principle

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Assumption of the Hardy-Weinberg Equilibrium

  • Allele frequencies do not change from generation to generation 
    • For any genetic locus, the genotype frequencies can be determined by the relative frequencies of the alleles at the locus 

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  • Note p is almost 1 (this is the case especially in rare diseases) 

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  • Using HW prevalence of PKU in population is 1/40,000=q2 hence q=1/200, therefore carrier = 2pq, which is about 2q=1/100

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