Flashcards in Dementia - Kruse Deck (4):
AChE inhibitors approved for use in dementia
2 main dementias that these are used for?
- Tacrine (HEPATOTOXICITY)
Dementia has a deficiency of cholinergic neurons
Treatment for AChE inhibitor overdose?
Memantine - MoA (explain)
Alzheimer's - glutamate may overstimulate various receptors, leading to neuronal cell death. During activation of the NMDA receptor, Mg leaves its intra-pore binding site and allows excess Ca++ influx.
MoA = antagonist at NDMA receptor by binding to Mg binding site (WHEN OVERLY ACTIVE) and preventing Ca++ influx