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Flashcards in Dementia - Kruse Deck (4):
1

AChE inhibitors approved for use in dementia




Why?

2 main dementias that these are used for?

- Donepezil
- Galantamine
- Rivastigmine
- Tacrine (HEPATOTOXICITY)

Dementia has a deficiency of cholinergic neurons

Alzheimer's, Parkinsons

2

Treatment for AChE inhibitor overdose?

Atropine
Pralidoxime (re-activator)

3

Memantine - MoA (explain)

Alzheimer's - glutamate may overstimulate various receptors, leading to neuronal cell death. During activation of the NMDA receptor, Mg leaves its intra-pore binding site and allows excess Ca++ influx.

MoA = antagonist at NDMA receptor by binding to Mg binding site (WHEN OVERLY ACTIVE) and preventing Ca++ influx

4

Memantine - side effect (most common)

Dizziness