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Flashcards in Depression Deck (56)
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1
Q

Serotonin syndrome is most common in what combo?

A

MAOI with another serotonergic agent

2
Q

What antidepressant carries the hugest risk of withdrawal symptoms

A

Paxil

3
Q

How long is an adequate trial of an antidepressant?

A

6-8 weeks

4
Q

What is in the combo Symbyax?

A

Olanzapine + fluoxetine

5
Q

Which antidepressants are started in pregnancy?

A

SSRIs

6
Q

Which SSRI is not recommended in pregnancy?

A

Paxil

7
Q

New warning from FDA SSRIs use in pregnancy can cause what risk?

A

Persistent pulmonary hypertension in the newborn

8
Q

What agents are preferred in postpartum depression?

A

SSRIs

Tricyclics

9
Q

Natural products depression?

A

St. John’s wort

SAMe

10
Q

Three negative things about St. John’s wort

A

Drug interactions
Serotonergic
Photosensitizer

11
Q

Use Symbyax when?

A

Resistant depression

12
Q

Which SSRI has the most drug interactions?

A

Fluvoxamine

13
Q

SSRI can cause what kind of side effects?

A

Sexual

14
Q

Which SSRI is the most activating and should be taken when?

A

Fluoxetine

In the morning

15
Q

Fluvoxamine is only approved for what?

A

OCD

16
Q

If cardiac risk present, avoid what SSRI?

A

Citalopram

17
Q

Use which SSRI in cardiac patients?

A

Setraline

18
Q

Physical symptoms of depression improve after how long of treatment?

A

Within a few weeks

19
Q

antidepressant that has SSRI and 5HT1A partial agonist activity

A

Viibryd

20
Q

What advantage does Viibryd have over SSRIs and SNRIs?

A

Less sexual side effects

21
Q

Fluoxetine inhibits what CYPs?

A

2D6

2C19

22
Q

Paxil inhibits what CYP?

A

2D6

23
Q

All SSRIs and SNRIs increase what risk with anticoagulants and anti platelets?

A

Bleeding

24
Q

What three antidepressants are SNRI?

A

Venlafaxine
Duloxetine
Desvenlafaxine

25
Q

SNRIs cause what 2 NE related side effects

A

Increase in BP

Excessive sweating

26
Q

Which SNRI carries highest of raising blood pressure?

A

Venlafaxine

Especially at higher doses

27
Q

Which SNRI can you see a ghost tablet?

A

Desvenlafaxine

28
Q

Although less than SSRIs, SNRIs can also cause what SE?

A

Sexual dysfunction

29
Q

What 4 MOAs do TCAs have?

A

Inhibit re uptake of NE
Inhibit re uptake of 5HT
Blocks ACh receptors
Blocks histamine receptors

30
Q

TCAs have what toxicity in overdose?

A

Cardiotoxicity

31
Q

TCAs cause what group of SE?

A

Anticholinergic

Blocks ACh receptors

32
Q

What 2 other unpleasant SE can TCAs cause?

A

Vivid dreams

Weight gain

33
Q

TCAs are metabolized by what CYP?

A

2D6

34
Q

TCAs have what additive risk?

A

QT prolongation

35
Q

Will vivid dreams with TCAs go away?

A

Yes

36
Q

TCAs can increase what vital sign?

A

BP

Blocks NE reuptake

37
Q

Monoamine oxidase does what?

A

Breaks down catecholamines

38
Q

What is the brand name of the selegiline patch?

A

EMSAM

39
Q

Selegiline has what MOA?

A

MAOI B selective inhibitor

40
Q

MAOIs cause what when used with other antidepressants?

A

Hypertensive crisis

41
Q

Allow a wash out period of how long when switching to or from an MAOI?

A

2 week

42
Q

Exception to 2 week wash out period when switching to or from MAOI?

A

Fluoxetine

Wait 5 weeks

43
Q

Avoid what kinds of foods with MAOIs?

A

Tyramine rich foods

44
Q

Change EMSAM patch how often?

A

Daily

45
Q

What three agents are NDRIs?

A

Buproprion
Mirtazapine
Trazodone

46
Q

Bupropion has what special indication?

A

Seasonal effective disorder

47
Q

Bupropion is used for what random indication?

A

Smoking cessation

48
Q

DNE what mg/day in bupropion? Why?

A

450 mg

Increases seizure risk

49
Q

Bupropion has no effect on serotonin and therefore no _____ SE?

A

Sexual

50
Q

Bupropion is CI in what two disease states?

A

Seizures

Anorexia / bulimia

51
Q

Bupropion has what beneficial SE?

A

Weight loss

52
Q

Mirtazapine causes what 2 SE?

A

Sedation

Weight gain

53
Q

Trazodone can cause what medical emergency?

A

Priapism

54
Q

Antipsychotics are approved for what kind of depression?

A

Treatment-resistant depression

55
Q

All antipsychotics increase risk of what in elderly people with psychosis or dementia?

A

Death

56
Q

What antipsychotics are approved in treatment resistant depression?

A

Abilify
Symbyax
Seroquel