Dermatological Topicals Flashcards
Mupirocin: type, spectrum, use
Antibiotic
Narrow, but gets many resistant Staphylococcus spp.
Superficial, localized skin lesions
Silver sulfadiazine (Silvadene, SSD): type, spectrum, uses (2)
Antibiotic
Broad spectrum
Superficial, localized skin infections
Burns
Topical ketoconazole, clotrimazole, miconazole: use
Superficial Malassezia sp. dermatitis, may be combined with systemic therapy
Lime sulfur: uses (4), caution
Dermatophytosis
Superficial Malassezia sp.
Mange
Lice
Wide margin of safety, but has a strong odor and will stain clothing
Topical Lidocaine: effect, use
Local anesthetic
Antipruritic
Benzocaine: effect, use
Local anesthetic
Antipruritic
Tetracaine: effect, use
Local anesthetic
Antipruritic
Pramoxine: effect, use
Local anesthetic
Antipruritic
Colloidal oatmeal: what is it? effects/uses (2)
Oatmeal ground into a very fine powder
Anti-inflammatory
Antipruritic
Phytosphingosine: what is it? effects (2), uses (3)
Ceramide - natural skin lipid that maintains kind barrier and controlled skin microbe population
Repairs skin lipid barrier
Anti-inflammatory
Allergic skin disease
Seborrhea
Other inflammatory skin disorders
Tacrolimus: effect, uses (2), caution
Reduces cell-mediated immunity
Atopic skin disease
Autoimmune disease
FDA Black Box Warning: increased risk of lymphoma and skin cancer in humans
Seborrhea
Increased production of keratinized skin cells
Primary - inherited
Secondary - allergic skin disease is the most common cause
Keratolytic
Removes excessive scaling
Softens skin
Keratoplastic
Slows down keratinization
Reduces scale formation
Antiseborrheic agents
Are keratolytic and/or keratoplastic
Some agents have additional therapeutic effects
Often used as part of a multi-modal therapy
