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Renal/Skeletal > Dermatology pharm > Flashcards

Flashcards in Dermatology pharm Deck (4)
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1

Topical steroid side effects

Skin atrophy
Telangiectasias
Purpura
Acne
Glaucoma
Skin infections
HPA axis suppression

2

Tacrolimus

Calcineurin inhibitor

MOA:
- Blocks translocation of DNA transcription factor that upregulates IL-2 (inflammatory factor)

Use:
- Stop topical steroid.
- Switch to calcineurin inhibitor to maintain remission.
- Can stop when completely clear.
- Restart topical steroid when reflare occurs.
- Repeat above steps.

Goal: maximize steroid-free intervals.

3

Pimecrolimus

Calcineurin inhibitor

MOA:
- Blocks translocation of DNA transcription factor that upregulates IL-2 (inflammatory factor)

Use:
- Stop topical steroid.
- Switch to calcineurin inhibitor to maintain remission.
- Can stop when completely clear.
- Restart topical steroid when reflare occurs.
- Repeat above steps.

Goal: maximize steroid-free intervals.

4

Retinoids

Tretinoin (topical medicine with limited systemic absorption)

Acitretin (Used for psoraisis, NOT in child-bearing women)

Isotretinoin (persistant, refractory acne vulgaris, scarring acne)

MOA: small molecule hormones which activate nuclear receptors and regulate gene transcription

Affect inflammation, cellular differentiation, apoptosis, and sebaceous gland activity.

Side effects:
- Cheilitis, dry skin, muscle enzyme abnormalities, elevated LFTS, triglycerides- need monthly labs
- Pseudotumor cerebri

Category X teratogen: need monthly pregnancy tests, 2 forms of birth control