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Flashcards in Development of the Urinary system Deck (36):
1

the urogenital system develops from what type of the mesoderm

intermediate mesoderm

2

the intermediate mesoderm forms a longitudinal ridge that is called ?

urogenital ridge

3

the kidneys develop in what type of sequence somatotopically

cranial to caudal

4

what are the 3 developing kidney systems in chronological order

-pronephros
-mesonephros
-metanephros

5

when and where does the pronephros develop ?

day 21-24
-cranially in the cervical segments of the intermediate cords

6

which kidney system is rudimentery and which becomes the adult kidney

pronephros - rudimentery/nonfunctional
metanephros - becomes functional kidney

7

when and where does the mesonephros develop

weeks 5-10
-thoracic and lumbar segments of the intermediate mesoderm

8

is the mesonephros functional ?

Yes, produces and drains urine during weeks 5-10

9

in the mesonephros what is the structure that drains the urine produced leading to the bladder

mesonephric duct (Wolfian duct)
- or nephrogenic duct

10

what develops into the primordial nephron ?

consolidation of about 40 mesonephric tubule

11

the mesonephric duct extends caudally untill it fuses with ____, making up the ____ portion of the bladder

cloaca, posterior portion

12

what initiate the formation of the uteric bud ?

canalization of the mesonephric cord

13

what is the adult derivative of the uteric bud

metanephric diverticulum

14

canalization of the mesonephric duct occurs in what direction somatotopically

caudal to cranial

15

what are the 2 componets of the metanephros

-Collection portion
-excretory portion

16

when and where does the uteric bud develop

week 5 in the distal portion of the mesonephric duct

17

the formation of the uteric bud induces the sacral region of the intermediate mesoderm to form what ?

metanephric blastema

18

the collecting portion of the metanephros develops from what ?

uteric bud

19

the excretory portion of the metanephros develops from what ?

metanephric blastma

20

what does reciprocal induction mean with reference to the metanephros

it means that the uteric bud is needed to "induce" nephron differentiation
-aka to induce the metanephric blastema
-if the uteric bud doesnt develop, then rest of kidney doesnt develop

21

what parts of the adult kidney arise from the collecting portion of the metanephros

-ureter
-renal pelvis
-major/minor calyces

22

what parts of the adult kidney arise from the excretory portion of the metanephros

-bowmans capsule
-PCT
-loop of henle
-DCT

23

when do the kidneys start to ascend and what causes them to ascend

around week 6-9
-growth in length of the embryo forces them cranially

24

As the kidney ascends does it drag its original vasculature with it, or develop new blood supply strategies

Does NOT drag
-develops new renal a..

25

What are the 3 potential clinical malformations if the kidneys do not ascend correctly

1 - pelvic kidney -ectopic/out of place
2 - horeshoe kidney
3 - supernumery arteries - >1 renal aa. entering hilum
******2 and 3 not cause long term effects*******

26

what is the cloacal membrane divided by what ?

urorectal septum

27

the urorectal septum divides the cloacal membrane into ?

-ventral urogenital sinus
-dorsal anorectal canal

28

what are the 3 parts of the ventral urogenital sinus and what do they become

-vesicle part - anterior portion of bladder
-pelvic part - urethra
-phallic part - spongy urethra (men)

29

what is the posterior aspect of the bladder made up of ?

-distal portions of the mesonephric duct

30

what is the trigone and where can it be found

a triangular region of pulled down mesonephric ducts forming the posterior aspect of the bladder

31

what makes up the posterior vs. anterior aspects of the bladder

posterior - trigone of mesonephric ducts
anterior - vesicle part of ventral urogenital sinus

32

what develops from the pelvic part of the urogenital sinus in women

entire urethra and vagina

33

what develops from the pelvic part of the urogenital sinus in men

prostatic and membranous urethra

34

what develops from the phallic part of the urogenital sinus in men

spongy urethra

35

what are the 3 possible types of clinical malformations when the intraembryonic allantois does close off properly from the cloacal membrane

1 - urachal cyst - pocket of swelling when both ends are pinched off
2 - urachal sinus - closure at 1 end and open on the other
3 - urachal fistula - allantois not closed at either end resulting in dripping urine from umbilicus

36

what is exstrophy of the bladder and how does it occur

where the mucosal lining of the bladder is outside the body wall b/c the closing off of the external oblique did not occur on the anterior abdominal wall