diabetes

Question 1

formin MOA

Answer 1

decreases hepatic glucose production + intestinal absorption of glucose, increase insulin sensitivity in muscles

Question 2

formin BBW

Answer 2

lactic acidosis

Question 3

formin ADEs

Answer 3

vitamin B deficiency, lactic acidosis

Question 4

diabetes drugs with high A1C reduction

Answer 4

biguanides, sulfonylureas, GLP-1 agonists, thazolidinediones

Question 5

diabetes drugs w/ hypoglycemia risk

Answer 5

sulfonylureas, meglitinides

Question 6

diabetes drugs w/ weight gain

Answer 6

sulfonylureas, thiazolidinediones

Question 7

most weight gain diabetes drug

Answer 7

tirzepatide (manjaro)

Question 8

most well-tolerated diabetes drug

Answer 8

DPP-4 inhibitors

Question 9

formin chemical class

Answer 9

biguanide

Question 10

amide, ride, zide, gli, glu chemical class

Answer 10

sulfonylureas

Question 11

sulfonylurea MOA

Answer 11

increase secretion of insulin in pancreatic B cells

Question 12

diabetes highest hypoglycemia risk

Answer 12

glyburide

Question 13

sulfonylurea disadvantage

Answer 13

B cell burnout

Question 14

gliflozan chemical class

Answer 14

SGLT2 inhibitor

Question 15

gliflozan MOA

Answer 15

decreased reabsorption of glucose, increase glucose excretion

Question 16

gliflozan indications

Answer 16

HF

Question 17

gliflozan disadvantages

Answer 17

UTIs

Question 18

gliptin chemical class

Answer 18

DPP-4 inhibitor

Question 19

gliptin MOA

Answer 19

increase incretins + insulin, decrease glucagon

Question 20

gliptin ADEs

Answer 20

respiratory tract infection + nasopharyngitis, joint pain

Question 21

gliflozan ADEs

Answer 21

genitourinary infections, necrotizing fascilis + ketoacidosis, amputation + bone fractures

Question 22

gliflozan contraindications

Answer 22

renal disease

Question 23

gliptin contraindications

Answer 23

pancreatitis, HF

Question 24

tide chemical class

Answer 24

GLP-1 agonist

Question 25

tide MOA

Answer 25

increase insulin + B cells, decrease glucagon + gastric emptying

Question 26

tide indications

Answer 26

weight management (liraglutide, semiglutide)

Question 27

tide contraindications

Answer 27

thyroid, endocrine neoplasm, pancreatitis

Question 28

tide advantages

Answer 28

ASCVD protection

Question 29

glitazone chemical class

Answer 29

thazolidinediones

Question 30

glitazone MOA

Answer 30

activates PPAR, decrease insulin resistance

Question 31

glitazone contraindications

Answer 31

class III-IV HF

Question 32

glitazone ADEs

Answer 32

edema, increased risk of bladder cancer + fractures

Question 33

glinide chemical class

Answer 33

meglitinides

Question 34

glinide MOA

Answer 34

secrete insulin in pancreatic B cells

Question 35

glinide ADEs

Answer 35

respiratory infection

Question 36

acarbose, miglitol chemical class

Answer 36

a glucosidase inhibitors

Question 37

acarbose, miglitol MOA

Answer 37

inhibits hydrolyzation of carbs, delays glucose absorption, decrease postprangial glucose

Question 38

acarbose, miglitol contraindications

Answer 38

GI, ketoacidosis, cirrhosis