Diabetes: pharmacokinetics, dosages, adverse reactions Flashcards Preview

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Flashcards in Diabetes: pharmacokinetics, dosages, adverse reactions Deck (31):
1

 

 

considerations for oral therapy in patients with T2DM

 

 

page 225

2

 

 

ADA algorithm for treatment

 

 

page 226

3

 

 

sulfonylureas pharmacokinetics

 

 

page 227

4

 

 

sulfonylurease dosages

 

 

page 228

5

 

 

sulfonylureas adverse reactions

  • CV: edema, syncope
  • DERM: rash, urticaria, pruritis, photsensitivity
  • EENT: blurry vision
  • ENDO: hypoglycemia, hyponatremia
  • GI: anorexia, N/V, diarrhea, gas, heartburn, constipation
  • HEM: aplastic anemia, hemolytic anemia, bone marrow depression, thrombocytopenia, agranulocytosis
  • MISC: disulfiram-like reaction especially if patient drinks alcohol
  • MS: arthralgia, leg cramps, myalgia, tremors
  • NEURO: anxiety, depression, dizziness, headache, insomnia
  • RENAL: minor diuretic effect

6

 

 

metformin pharmacokinetics

 

 

 

page 229

7

 

 

dosing of metformin and metformin combinations

 

 

page 229

8

 

 

metformin adverse reactions

 

  • GI: abdominal pain, nausea, diarrhea, bloating, metallic taste
  • META: hypoglycemia, lactic acidosis (rare)
    • higher risk of lactic acidosis with renal dysfunction, increased age, DM, HF, other conditions having risks for hypoperfucion and hypoxemia
  • MISC: decreased B12 levels

9

 

 

meglitinide dosages

 

 

page 230

10

 

 

meglitidine pharmacokinetics

 

 

page 230

11

 

 

meglitinide adverse reactions

 

 

page 230

12

 

 

TZD pharmacokinetics

 

 

page 231

13

 

 

TZD dosages

 

 

page 231

14

 

 

TZD adverse reactions

 

 

page 232

15

 

 

alpha-glucosidase inhibitor pharmacokinetics

 

 

page 232

16

 

 

alpha-glucosidase inhibitor dosage

 

 

page 232

17

 

 

alpha-glucosidase inhibitor adverse reactions

 

 

page 233

18

 

 

amylin analogue pharmacokinetics

 

 

page 233

19

 

 

amylin analogue dosage

 

 

page 233

20

 

 

amylin analogue adverse reactions

 

 

page 234

21

 

 

GLP-1 agonists pharmacokinetics

 

 

page 234

22

 

 

GLP-1 agonists dosage

 

 

page 234

23

 

 

GLP-1 agonists adverse reactions

 

 

page 234

24

 

 

DDP-IV pharmacokinetics

 

 

page 235

25

 

 

DDP-IV dosage

 

 

page 235

26

 

 

DDP-IV adverse reactions

 

 

page 235

27

 

 

glucagon pharmacokinetics

 

 

page 236

28

 

 

glucagon dosage

 

 

page 236

29

 

 

glucagon adverse reactions

 

page 236

30

 

 

insulin pharmacokinetics

 

 

pag 238

31

 

 

onset/peak/duration of insulins

 

 

page 238